TY - JOUR
T1 - Avoiding Toxicity With Lung Radiation Therapy
T2 - An IASLC Perspective
AU - International Association for the Study of Lung Cancer Advanced Radiation Technology Committee
AU - Bucknell, Nicholas W.
AU - Belderbos, José
AU - Palma, David A.
AU - Iyengar, Puneeth
AU - Samson, Pamela
AU - Chua, Kevin
AU - Gomez, Daniel
AU - McDonald, Fiona
AU - Louie, Alexander V.
AU - Faivre-Finn, Corinne
AU - Hanna, Gerard G.
AU - Siva, Shankar
N1 - Publisher Copyright:
© 2022
PY - 2022/8
Y1 - 2022/8
N2 - Toxicity concerns from thoracic radiation therapy in the treatment of lung cancers have changed substantially over the past few decades. Survival in the treatment of lung cancer has markedly improved and the introduction of advanced radiation and imaging techniques to treatment planning and delivery has made reducing toxicity possible. Phase 3 dose-escalation trials have revealed that excess dose to critical organs within the thorax can negatively impact overall survival. We summarize the existing literature on the known toxicities of thoracic radiation therapy, summarize the technological advances that have made toxicity reduction possible, and provide an overview of emerging technologies and biomarkers that are being evaluated to assess future toxicity reductions.
AB - Toxicity concerns from thoracic radiation therapy in the treatment of lung cancers have changed substantially over the past few decades. Survival in the treatment of lung cancer has markedly improved and the introduction of advanced radiation and imaging techniques to treatment planning and delivery has made reducing toxicity possible. Phase 3 dose-escalation trials have revealed that excess dose to critical organs within the thorax can negatively impact overall survival. We summarize the existing literature on the known toxicities of thoracic radiation therapy, summarize the technological advances that have made toxicity reduction possible, and provide an overview of emerging technologies and biomarkers that are being evaluated to assess future toxicity reductions.
KW - Early-stage lung cancer
KW - Locally advanced lung cancer
KW - Non–small cell lung cancer
KW - Radiation toxicity
KW - Small cell lung cancer
KW - Stereotactic body radiation therapy
UR - http://www.scopus.com/inward/record.url?scp=85133298233&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85133298233&partnerID=8YFLogxK
U2 - 10.1016/j.jtho.2022.05.003
DO - 10.1016/j.jtho.2022.05.003
M3 - Review article
C2 - 35649502
AN - SCOPUS:85133298233
SN - 1556-0864
VL - 17
SP - 961
EP - 973
JO - Journal of Thoracic Oncology
JF - Journal of Thoracic Oncology
IS - 8
ER -