Azathioprine myelosuppression in multiple sclerosis: Characterizing thiopurine methyltransferase polymorphisms

Elliot Frohman, E. Havrdova, B. Levinson, O. Slanar

Research output: Contribution to journalArticle

6 Scopus citations


We describe two multiple sclerosis patients who developed pancytopenia following treatment with azathioprine. They were found to have the homozygous polymorphism for thiopurine methyltransferase deficiency and recovered after cessation of drug therapy. We review the literature concerning this molecular derangement and underscore the importance of performing surveillance testing for allelic characterization prior to treatment intervention with this agent for immune-mediated disorders.

Original languageEnglish (US)
Pages (from-to)108-111
Number of pages4
JournalMultiple Sclerosis
Issue number1
Publication statusPublished - Feb 2006



  • Azathioprine
  • Methytransferase
  • Polymorphism
  • Thiopurine

ASJC Scopus subject areas

  • Clinical Neurology

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