Azathioprine myelosuppression in multiple sclerosis: Characterizing thiopurine methyltransferase polymorphisms

Elliot Frohman; E. Havrdova; B. Levinson; O. Slanar

doi:10.1191/135248506ms1249cr

Azathioprine myelosuppression in multiple sclerosis: Characterizing thiopurine methyltransferase polymorphisms

Elliot Frohman, E. Havrdova, B. Levinson, O. Slanar

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

We describe two multiple sclerosis patients who developed pancytopenia following treatment with azathioprine. They were found to have the homozygous polymorphism for thiopurine methyltransferase deficiency and recovered after cessation of drug therapy. We review the literature concerning this molecular derangement and underscore the importance of performing surveillance testing for allelic characterization prior to treatment intervention with this agent for immune-mediated disorders.

Original language	English (US)
Pages (from-to)	108-111
Number of pages	4
Journal	Multiple Sclerosis
Volume	12
Issue number	1
DOIs	https://doi.org/10.1191/135248506ms1249cr
State	Published - Feb 2006

Keywords

Azathioprine
Methytransferase
Polymorphism
Thiopurine

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1191/135248506ms1249cr

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abstract = "We describe two multiple sclerosis patients who developed pancytopenia following treatment with azathioprine. They were found to have the homozygous polymorphism for thiopurine methyltransferase deficiency and recovered after cessation of drug therapy. We review the literature concerning this molecular derangement and underscore the importance of performing surveillance testing for allelic characterization prior to treatment intervention with this agent for immune-mediated disorders.",

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AU - Havrdova, E.

AU - Levinson, B.

AU - Slanar, O.

PY - 2006/2

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AB - We describe two multiple sclerosis patients who developed pancytopenia following treatment with azathioprine. They were found to have the homozygous polymorphism for thiopurine methyltransferase deficiency and recovered after cessation of drug therapy. We review the literature concerning this molecular derangement and underscore the importance of performing surveillance testing for allelic characterization prior to treatment intervention with this agent for immune-mediated disorders.

KW - Azathioprine

KW - Methytransferase

KW - Polymorphism

KW - Thiopurine

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Azathioprine myelosuppression in multiple sclerosis: Characterizing thiopurine methyltransferase polymorphisms

Abstract

Keywords

ASJC Scopus subject areas

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