AZD5438, an inhibitor of Cdk1, 2, and 9, enhances the radiosensitivity of non-small cell lung carcinoma cells

Physics & Astronomy

• radiation tolerance 52%
• inhibitors 52%
• lungs 48%
• cancer 41%
• tumors 34%
• radiation therapy 26%
• apoptosis 24%
• cultured cells 21%
• strands 18%
• deoxyribonucleic acid 16%
• metastasis 13%
• lymphatic system 12%
• animal models 12%
• augmentation 10%
• progressions 10%
• mice 9%
• ionizing radiation 9%
• cycles 5%
• dosage 5%
• irradiation 5%
• evaluation 5%
• radiation 4%
• cells 4%

Medicine & Life Sciences

• AZD5438 100%
• Radiation Tolerance 51%
• Non-Small Cell Lung Carcinoma 40%
• Cyclin-Dependent Kinases 17%
• Double-Stranded DNA Breaks 17%
• A549 Cells 16%
• Radiotherapy 15%
• Nude Mice 14%
• Radiation 11%
• Recombinational DNA Repair 9%
• Neoplasms 9%
• Apoptosis 9%
• Homologous Recombination 8%
• Ionizing Radiation 7%
• Heterografts 6%
• Evaluation Studies 6%
• Cell Cycle 5%
• Animal Models 5%
• Lymph Nodes 5%
• Neoplasm Metastasis 4%
• Growth 3%
• Therapeutics 3%
• In Vitro Techniques 3%