Aztreonam therapy in experimental meningitis due to Haemophilus influenza type b and Escherichia coli K1

G. H. McCracken, Y. Sakata, K. D. Olsen

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The penetration of aztreonam into cerebrospinal fluid was 7 to 15% and 9 to 25%, respectively, in experimental Haemophilus influenzae type b and Escherichia coli K1 meningitis. Aztreonam was effective in reducing the number of organisms in cerebrospinal fluid after single-dose and continuous infusion administration, and the median bactericidal titers in cerebrospinal fluid were 1:32 against both meningeal pathogens.

Original languageEnglish (US)
Pages (from-to)655-656
Number of pages2
JournalAntimicrobial agents and chemotherapy
Volume27
Issue number4
DOIs
StatePublished - Jan 1 1985

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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