Abstract
The penetration of aztreonam into cerebrospinal fluid was 7 to 15% and 9 to 25%, respectively, in experimental Haemophilus influenzae type b and Escherichia coli K1 meningitis. Aztreonam was effective in reducing the number of organisms in cerebrospinal fluid after single-dose and continuous infusion administration, and the median bactericidal titers in cerebrospinal fluid were 1:32 against both meningeal pathogens.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 655-656 |
| Number of pages | 2 |
| Journal | Antimicrobial agents and chemotherapy |
| Volume | 27 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1985 |
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases