The penetration of aztreonam into cerebrospinal fluid was 7 to 15% and 9 to 25%, respectively, in experimental Haemophilus influenzae type b and Escherichia coli K1 meningitis. Aztreonam was effective in reducing the number of organisms in cerebrospinal fluid after single-dose and continuous infusion administration, and the median bactericidal titers in cerebrospinal fluid were 1:32 against both meningeal pathogens.
|Original language||English (US)|
|Number of pages||2|
|Journal||Antimicrobial Agents and Chemotherapy|
|Publication status||Published - 1985|
ASJC Scopus subject areas
- Pharmacology (medical)