Abstract
We have introduced general ways in which B cells play a role in protective immunity against microbes. Although B cells were originally defined solely as antibody-producing cells, it is now known that they have other functions that are equally as important as producing antibodies. These include antigen-presenting cell activity and the production of natural IgM antibodies that trigger complement activation. Future research will undoubtedly help define how changes in B-cell functions following injury and sepsis affect the development of effective or suppressive immunity in patients who are predisposed to sepsis, are undergoing sepsis, or are in septic shock.
Original language | English (US) |
---|---|
Journal | Critical Care Medicine |
Volume | 33 |
Issue number | 12 SUPPL. |
DOIs | |
State | Published - Dec 2005 |
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ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine
Cite this
B cells. / MacConmara, Malcolm; Lederer, James A.
In: Critical Care Medicine, Vol. 33, No. 12 SUPPL., 12.2005.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - B cells
AU - MacConmara, Malcolm
AU - Lederer, James A.
PY - 2005/12
Y1 - 2005/12
N2 - We have introduced general ways in which B cells play a role in protective immunity against microbes. Although B cells were originally defined solely as antibody-producing cells, it is now known that they have other functions that are equally as important as producing antibodies. These include antigen-presenting cell activity and the production of natural IgM antibodies that trigger complement activation. Future research will undoubtedly help define how changes in B-cell functions following injury and sepsis affect the development of effective or suppressive immunity in patients who are predisposed to sepsis, are undergoing sepsis, or are in septic shock.
AB - We have introduced general ways in which B cells play a role in protective immunity against microbes. Although B cells were originally defined solely as antibody-producing cells, it is now known that they have other functions that are equally as important as producing antibodies. These include antigen-presenting cell activity and the production of natural IgM antibodies that trigger complement activation. Future research will undoubtedly help define how changes in B-cell functions following injury and sepsis affect the development of effective or suppressive immunity in patients who are predisposed to sepsis, are undergoing sepsis, or are in septic shock.
UR - http://www.scopus.com/inward/record.url?scp=28944448283&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=28944448283&partnerID=8YFLogxK
U2 - 10.1097/01.CCM.0000190616.15952.4B
DO - 10.1097/01.CCM.0000190616.15952.4B
M3 - Article
C2 - 16340437
AN - SCOPUS:28944448283
VL - 33
JO - Critical Care Medicine
JF - Critical Care Medicine
SN - 0090-3493
IS - 12 SUPPL.
ER -