B cells

Malcolm MacConmara, James A. Lederer

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We have introduced general ways in which B cells play a role in protective immunity against microbes. Although B cells were originally defined solely as antibody-producing cells, it is now known that they have other functions that are equally as important as producing antibodies. These include antigen-presenting cell activity and the production of natural IgM antibodies that trigger complement activation. Future research will undoubtedly help define how changes in B-cell functions following injury and sepsis affect the development of effective or suppressive immunity in patients who are predisposed to sepsis, are undergoing sepsis, or are in septic shock.

Original languageEnglish (US)
JournalCritical Care Medicine
Volume33
Issue number12 SUPPL.
DOIs
StatePublished - Dec 2005

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Sepsis
B-Lymphocytes
Immunity
Antibody-Producing Cells
Antibodies
Complement Activation
Antigen-Presenting Cells
Septic Shock
Immunoglobulin M
Wounds and Injuries

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

B cells. / MacConmara, Malcolm; Lederer, James A.

In: Critical Care Medicine, Vol. 33, No. 12 SUPPL., 12.2005.

Research output: Contribution to journalArticle

MacConmara, Malcolm ; Lederer, James A. / B cells. In: Critical Care Medicine. 2005 ; Vol. 33, No. 12 SUPPL.
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