Abstract
We have introduced general ways in which B cells play a role in protective immunity against microbes. Although B cells were originally defined solely as antibody-producing cells, it is now known that they have other functions that are equally as important as producing antibodies. These include antigen-presenting cell activity and the production of natural IgM antibodies that trigger complement activation. Future research will undoubtedly help define how changes in B-cell functions following injury and sepsis affect the development of effective or suppressive immunity in patients who are predisposed to sepsis, are undergoing sepsis, or are in septic shock.
| Original language | English (US) |
|---|---|
| Journal | Critical Care Medicine |
| Volume | 33 |
| Issue number | 12 SUPPL. |
| DOIs | |
| State | Published - Dec 2005 |
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ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine
Cite this
B cells. / MacConmara, Malcolm; Lederer, James A.
In: Critical Care Medicine, Vol. 33, No. 12 SUPPL., 12.2005.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - B cells
AU - MacConmara, Malcolm
AU - Lederer, James A.
PY - 2005/12
Y1 - 2005/12
N2 - We have introduced general ways in which B cells play a role in protective immunity against microbes. Although B cells were originally defined solely as antibody-producing cells, it is now known that they have other functions that are equally as important as producing antibodies. These include antigen-presenting cell activity and the production of natural IgM antibodies that trigger complement activation. Future research will undoubtedly help define how changes in B-cell functions following injury and sepsis affect the development of effective or suppressive immunity in patients who are predisposed to sepsis, are undergoing sepsis, or are in septic shock.
AB - We have introduced general ways in which B cells play a role in protective immunity against microbes. Although B cells were originally defined solely as antibody-producing cells, it is now known that they have other functions that are equally as important as producing antibodies. These include antigen-presenting cell activity and the production of natural IgM antibodies that trigger complement activation. Future research will undoubtedly help define how changes in B-cell functions following injury and sepsis affect the development of effective or suppressive immunity in patients who are predisposed to sepsis, are undergoing sepsis, or are in septic shock.
UR - http://www.scopus.com/inward/record.url?scp=28944448283&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=28944448283&partnerID=8YFLogxK
U2 - 10.1097/01.CCM.0000190616.15952.4B
DO - 10.1097/01.CCM.0000190616.15952.4B
M3 - Article
C2 - 16340437
AN - SCOPUS:28944448283
VL - 33
JO - Critical Care Medicine
JF - Critical Care Medicine
SN - 0090-3493
IS - 12 SUPPL.
ER -