B cells from relapsing remitting multiple sclerosis patients support neuro-antigen-specific Th17 responses

Sara J. Ireland, Alyssa A. Guzman, Elliot Frohman, Nancy L Monson

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

B cells are highly potent antigen presenting cells of their cognate antigens. However, it remains unknown whether B cells can orchestrate Th17-mediated responses against neuro-antigens. We report that MS patients and healthy donors had a similar frequency of antigen-specific Th1 and Th17 cells, and distribution of T effector and T central memory cells. Notwithstanding these similarities, the application of an in vitro assay demonstrated that the B cells derived from a subset of MS patients exhibited the capability of coordinating Th17 responses directed toward neuro-antigens. These observations underscore the B cell's contribution to the putative underpinnings of multiple sclerosis.

Original languageEnglish (US)
Pages (from-to)46-53
Number of pages8
JournalJournal of Neuroimmunology
Volume291
DOIs
StatePublished - Feb 15 2016

Keywords

  • B cells
  • Multiple sclerosis
  • Th17 cells

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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