B-cells in systemic sclerosis: Emerging evidence from genetics to phenotypes

Minghua Wu, Chandra Mohan

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Purpose of review. This review aims to summarize current evidence for a role of B-cells in the pathogenesis of systemic sclerosis (SSc) from genetics to phenotypes, with an emphasis on recent insights. Recent findings. Multiple genomic analyses have associated several B-cell signalling genes with SSc. Moreover, interesting B-cell subset alterations and activation/memory marker changes have also been documented in SSc. Co-cultures of blood B-cells with dermal fibroblasts isolated from SSc patients demonstrated the induction of collagen, interleukin (IL)-6, transforming growth factor (TGF)-β1, IL-1β and chemokine (c-c motif) ligand 2 (CCL2) in the fibroblasts, following potential B-cell cues delivered to the fibroblasts. Plasma cell gene signatures were elevated in SSc patients' blood, and highly correlated with collagen gene expression. Finally, anti-CD20 B-cell depletion therapy not only improved skin disease but also preserved interstitial lung disease in early diffuse cutaneous disease. Summary. Thus, there is resounding evidence that B-cells play a pivotal role in pathogenesis of SSc. However, the molecular pathways through which B-cells may direct fibroblast function, SSc disease development and progression remain unclear, and warrant further study.

Original languageEnglish (US)
Pages (from-to)537-541
Number of pages5
JournalCurrent Opinion in Rheumatology
Volume27
Issue number6
DOIs
StatePublished - Nov 1 2015

Keywords

  • Antibodies
  • Autoimmunity
  • Cytokines
  • Fibrosis
  • Systemic sclerosis

ASJC Scopus subject areas

  • Rheumatology

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