B lymphocytes in neuromyelitis optica

Jeffrey L. Bennett, Kevin C. O'Connor, Amit Bar-Or, Scott S. Zamvil, Bernhard Hemmer, Thomas F. Tedder, H. Christian Von Budingen, Olaf Stuve, Michael R. Yeaman, Terry J. Smith, Christine Stadelmann

Research output: Contribution to journalReview article

42 Citations (Scopus)

Abstract

Neuromyelitis optica (NMO) is an inflammatory autoimmune disorder of the CNS that predominantly affects the spinal cord and optic nerves. A majority (approximately 75%) of patients with NMO are seropositive for autoantibodies against the astrocyte water channel aquaporin-4 (AQP4). These autoantibodies are predominantly IgG1, and considerable evidence supports their pathogenicity, presumably by binding to AQP4 on CNS astrocytes, resulting in astrocyte injury and inflammation. Convergent clinical and laboratory-based investigations have indicated that B cells play a fundamental role in NMO immunopathology. Multiple mechanisms have been hypothesized: AQP4 autoantibody production, enhanced proinflammatory B cell and plasmablast activity, aberrant B cell tolerance checkpoints, diminished B cell regulatory function, and loss of B cell anergy. Accordingly, many current off-label therapies for NMO deplete B cells or modulate their activity. Understanding the role and mechanisms whereby B cells contribute to initiation, maintenance, and propagation of disease activity is important to advancing our understanding of NMO pathogenesis and developing effective disease-specific therapies.

Original languageEnglish (US)
Pages (from-to)e104
JournalNeurology: Neuroimmunology and NeuroInflammation
Volume2
Issue number3
DOIs
StatePublished - Jun 1 2015

Fingerprint

Neuromyelitis Optica
B-Lymphocytes
Aquaporin 4
Astrocytes
Autoantibodies
Regulatory B-Lymphocytes
Spinal Nerves
Aquaporins
Optic Nerve
Virulence
Spinal Cord
Immunoglobulin G
Maintenance
Inflammation
Wounds and Injuries
Therapeutics

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Bennett, J. L., O'Connor, K. C., Bar-Or, A., Zamvil, S. S., Hemmer, B., Tedder, T. F., ... Stadelmann, C. (2015). B lymphocytes in neuromyelitis optica. Neurology: Neuroimmunology and NeuroInflammation, 2(3), e104. https://doi.org/10.1212/NXI.0000000000000104

B lymphocytes in neuromyelitis optica. / Bennett, Jeffrey L.; O'Connor, Kevin C.; Bar-Or, Amit; Zamvil, Scott S.; Hemmer, Bernhard; Tedder, Thomas F.; Von Budingen, H. Christian; Stuve, Olaf; Yeaman, Michael R.; Smith, Terry J.; Stadelmann, Christine.

In: Neurology: Neuroimmunology and NeuroInflammation, Vol. 2, No. 3, 01.06.2015, p. e104.

Research output: Contribution to journalReview article

Bennett, JL, O'Connor, KC, Bar-Or, A, Zamvil, SS, Hemmer, B, Tedder, TF, Von Budingen, HC, Stuve, O, Yeaman, MR, Smith, TJ & Stadelmann, C 2015, 'B lymphocytes in neuromyelitis optica', Neurology: Neuroimmunology and NeuroInflammation, vol. 2, no. 3, pp. e104. https://doi.org/10.1212/NXI.0000000000000104
Bennett JL, O'Connor KC, Bar-Or A, Zamvil SS, Hemmer B, Tedder TF et al. B lymphocytes in neuromyelitis optica. Neurology: Neuroimmunology and NeuroInflammation. 2015 Jun 1;2(3):e104. https://doi.org/10.1212/NXI.0000000000000104
Bennett, Jeffrey L. ; O'Connor, Kevin C. ; Bar-Or, Amit ; Zamvil, Scott S. ; Hemmer, Bernhard ; Tedder, Thomas F. ; Von Budingen, H. Christian ; Stuve, Olaf ; Yeaman, Michael R. ; Smith, Terry J. ; Stadelmann, Christine. / B lymphocytes in neuromyelitis optica. In: Neurology: Neuroimmunology and NeuroInflammation. 2015 ; Vol. 2, No. 3. pp. e104.
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