B-type natriuretic peptides in acute coronary syndromes: Implications in an aging population

Selim R. Krim, Rey P. Vivo, James A de Lemos

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

B-type natriuretic peptide (BNP) and N-terminal-proBNP (NT-proBNP) are increasingly recognized as prognostic markers in patients with acute coronary syndrome (ACS). The need for novel and more effective tools for risk assessment cannot be more emphasized than in older patients with ACS given their atypical presentation, multiple comorbidities, and higher risk for mortality and morbidity. Accurate interpretation of B-type NP values in older patients with ACS, however, may be confounded by several aging-related physiologic changes. Advanced age, reduction in body mass, and kidney function and anemia have been associated with higher BNP and NT-proBNP concentrations, and may create challenges with interpreting NP levels in the elderly. This review highlights the need to better understand the physiology of BNP and NT-proBNP in older individuals and their prognostic value in older patients with ACS.

Original languageEnglish (US)
Pages (from-to)682-685
Number of pages4
JournalClinical Cardiology
Volume35
Issue number11
DOIs
StatePublished - Nov 2012

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Brain Natriuretic Peptide
Acute Coronary Syndrome
Population
Comorbidity
Anemia
Morbidity
Kidney
Mortality
pro-brain natriuretic peptide (1-76)

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

B-type natriuretic peptides in acute coronary syndromes : Implications in an aging population. / Krim, Selim R.; Vivo, Rey P.; de Lemos, James A.

In: Clinical Cardiology, Vol. 35, No. 11, 11.2012, p. 682-685.

Research output: Contribution to journalArticle

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