B7DC/PDL2 promotes tumor immunity by a PD-1-independent mechanism

Xingluo Liu, Jian Xin Gao, Jing Wen, Lijie Yin, Ou Li, Tao Zuo, Thomas F. Gajewski, Yang Xin Fu, Pan Zheng, Yang Liu

Research output: Contribution to journalArticlepeer-review

119 Scopus citations

Abstract

B7H1 (PDL1) and B7DC (PDL2) are two new members of the B7 family that can interact with PD-1, a putative negative regulator for immune function. Recent studies have provided evidence for inhibitory functions of both members via PD-1. Meanwhile, compelling evidence exists for costimulatory function of both members. Here we demonstrate that expression of B7DC on the tumor cells promotes CD8 T cell-mediated rejection of tumor cells, at both the induction and effector phase of antitumor immunity. Moreover, B7DC binds to PD-1(-/-) cells and enhances T cell killing in a PD-1-independent mechanism. Our results demonstrate a novel pathway for B7DC to promote tumor immunity and may reconcile the apparently contradictory findings on the function of B7DC.

Original languageEnglish (US)
Pages (from-to)1721-1730
Number of pages10
JournalJournal of Experimental Medicine
Volume197
Issue number12
DOIs
StatePublished - Jun 16 2003

Keywords

  • Costimulatory molecules
  • Cytolytic T lymphocytes
  • Tumor immunity

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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