B7DC/PDL2 promotes tumor immunity by a PD-1-independent mechanism

Xingluo Liu, Jian Xin Gao, Jing Wen, Lijie Yin, Ou Li, Tao Zuo, Thomas F. Gajewski, Yang Xin Fu, Pan Zheng, Yang Liu

Research output: Contribution to journalArticle

116 Citations (Scopus)

Abstract

B7H1 (PDL1) and B7DC (PDL2) are two new members of the B7 family that can interact with PD-1, a putative negative regulator for immune function. Recent studies have provided evidence for inhibitory functions of both members via PD-1. Meanwhile, compelling evidence exists for costimulatory function of both members. Here we demonstrate that expression of B7DC on the tumor cells promotes CD8 T cell-mediated rejection of tumor cells, at both the induction and effector phase of antitumor immunity. Moreover, B7DC binds to PD-1(-/-) cells and enhances T cell killing in a PD-1-independent mechanism. Our results demonstrate a novel pathway for B7DC to promote tumor immunity and may reconcile the apparently contradictory findings on the function of B7DC.

Original languageEnglish (US)
Pages (from-to)1721-1730
Number of pages10
JournalJournal of Experimental Medicine
Volume197
Issue number12
DOIs
StatePublished - Jun 16 2003

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Immunity
T-Lymphocytes
Neoplasms
Rejection (Psychology)

Keywords

  • Costimulatory molecules
  • Cytolytic T lymphocytes
  • Tumor immunity

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Liu, X., Xin Gao, J., Wen, J., Yin, L., Li, O., Zuo, T., ... Liu, Y. (2003). B7DC/PDL2 promotes tumor immunity by a PD-1-independent mechanism. Journal of Experimental Medicine, 197(12), 1721-1730. https://doi.org/10.1084/jem.20022089

B7DC/PDL2 promotes tumor immunity by a PD-1-independent mechanism. / Liu, Xingluo; Xin Gao, Jian; Wen, Jing; Yin, Lijie; Li, Ou; Zuo, Tao; Gajewski, Thomas F.; Fu, Yang Xin; Zheng, Pan; Liu, Yang.

In: Journal of Experimental Medicine, Vol. 197, No. 12, 16.06.2003, p. 1721-1730.

Research output: Contribution to journalArticle

Liu, X, Xin Gao, J, Wen, J, Yin, L, Li, O, Zuo, T, Gajewski, TF, Fu, YX, Zheng, P & Liu, Y 2003, 'B7DC/PDL2 promotes tumor immunity by a PD-1-independent mechanism', Journal of Experimental Medicine, vol. 197, no. 12, pp. 1721-1730. https://doi.org/10.1084/jem.20022089
Liu, Xingluo ; Xin Gao, Jian ; Wen, Jing ; Yin, Lijie ; Li, Ou ; Zuo, Tao ; Gajewski, Thomas F. ; Fu, Yang Xin ; Zheng, Pan ; Liu, Yang. / B7DC/PDL2 promotes tumor immunity by a PD-1-independent mechanism. In: Journal of Experimental Medicine. 2003 ; Vol. 197, No. 12. pp. 1721-1730.
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