Background and rationale for the sequenced treatment alternatives to relieve depression (STAR*D) study

Maurizio Fava; A. John Rush; Madhukar H. Trivedi; Andrew A. Nierenberg; Michael E. Thase; Harold A. Sackeim; Frederic M. Quitkin; Steven Wisniewski; Philip W. Lavori; Jerrold F. Rosenbaum; David J. Kupfer

doi:10.1016/S0193-953X(02)00107-7

Background and rationale for the sequenced treatment alternatives to relieve depression (STAR*D) study

Maurizio Fava, A. John Rush, Madhukar H. Trivedi, Andrew A. Nierenberg, Michael E. Thase, Harold A. Sackeim, Frederic M. Quitkin, Steven Wisniewski, Philip W. Lavori, Jerrold F. Rosenbaum, David J. Kupfer

Research output: Contribution to journal › Review article › peer-review

449 Scopus citations

Abstract

Sequenced Treatment Alternatives to Relieve Depression (STAR*D) attempts to fill in major clinical information gaps and to evaluate the theoretical principles and clinical beliefs that currently guide pharmacotherapy of major depressive disorder. The study is conducted in representative participant groups and settings using clinical management tools that easily can be applied in daily practice. Outcomes include clinical outcomes and health care utilization and cost estimates. Research findings should be immediately applicable to, and easily implemented in, the daily primary and specialty care practices. This article provides the overall rationale for STAR*D and details the rationale for key design, measurement, and analytic features of the study.

Original language	English (US)
Pages (from-to)	457-494
Number of pages	38
Journal	Psychiatric Clinics of North America
Volume	26
Issue number	2
DOIs	https://doi.org/10.1016/S0193-953X(02)00107-7
State	Published - Jun 2003

ASJC Scopus subject areas

Psychiatry and Mental health

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Fava, M., Rush, A. J., Trivedi, M. H., Nierenberg, A. A., Thase, M. E., Sackeim, H. A., Quitkin, F. M., Wisniewski, S., Lavori, P. W., Rosenbaum, J. F., & Kupfer, D. J. (2003). Background and rationale for the sequenced treatment alternatives to relieve depression (STAR*D) study. Psychiatric Clinics of North America, 26(2), 457-494. https://doi.org/10.1016/S0193-953X(02)00107-7

Background and rationale for the sequenced treatment alternatives to relieve depression (STAR*D) study. / Fava, Maurizio; Rush, A. John; Trivedi, Madhukar H.; Nierenberg, Andrew A.; Thase, Michael E.; Sackeim, Harold A.; Quitkin, Frederic M.; Wisniewski, Steven; Lavori, Philip W.; Rosenbaum, Jerrold F.; Kupfer, David J.

In: Psychiatric Clinics of North America, Vol. 26, No. 2, 06.2003, p. 457-494.

Research output: Contribution to journal › Review article › peer-review

Fava, Maurizio ; Rush, A. John ; Trivedi, Madhukar H. ; Nierenberg, Andrew A. ; Thase, Michael E. ; Sackeim, Harold A. ; Quitkin, Frederic M. ; Wisniewski, Steven ; Lavori, Philip W. ; Rosenbaum, Jerrold F. ; Kupfer, David J. / Background and rationale for the sequenced treatment alternatives to relieve depression (STAR*D) study. In: Psychiatric Clinics of North America. 2003 ; Vol. 26, No. 2. pp. 457-494.

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