TY - JOUR
T1 - Background and rationale for the sequenced treatment alternatives to relieve depression (STAR*D) study
AU - Fava, Maurizio
AU - Rush, A. John
AU - Trivedi, Madhukar H.
AU - Nierenberg, Andrew A.
AU - Thase, Michael E.
AU - Sackeim, Harold A.
AU - Quitkin, Frederic M.
AU - Wisniewski, Steven
AU - Lavori, Philip W.
AU - Rosenbaum, Jerrold F.
AU - Kupfer, David J.
N1 - Funding Information:
Supported in part by National Institutes of Mental Health Contract N01-MH-90003, the Betty Jo Hay Distinguished Chair in Mental Health, the Rosewood Corporation Chair in Biomedical Science, and the Sara M. and Charles E. Seay Center for Basic and Applied Research in Psychiatry.
PY - 2003/6
Y1 - 2003/6
N2 - Sequenced Treatment Alternatives to Relieve Depression (STAR*D) attempts to fill in major clinical information gaps and to evaluate the theoretical principles and clinical beliefs that currently guide pharmacotherapy of major depressive disorder. The study is conducted in representative participant groups and settings using clinical management tools that easily can be applied in daily practice. Outcomes include clinical outcomes and health care utilization and cost estimates. Research findings should be immediately applicable to, and easily implemented in, the daily primary and specialty care practices. This article provides the overall rationale for STAR*D and details the rationale for key design, measurement, and analytic features of the study.
AB - Sequenced Treatment Alternatives to Relieve Depression (STAR*D) attempts to fill in major clinical information gaps and to evaluate the theoretical principles and clinical beliefs that currently guide pharmacotherapy of major depressive disorder. The study is conducted in representative participant groups and settings using clinical management tools that easily can be applied in daily practice. Outcomes include clinical outcomes and health care utilization and cost estimates. Research findings should be immediately applicable to, and easily implemented in, the daily primary and specialty care practices. This article provides the overall rationale for STAR*D and details the rationale for key design, measurement, and analytic features of the study.
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U2 - 10.1016/S0193-953X(02)00107-7
DO - 10.1016/S0193-953X(02)00107-7
M3 - Review article
C2 - 12778843
AN - SCOPUS:0037986382
VL - 26
SP - 457
EP - 494
JO - Psychiatric Clinics of North America
JF - Psychiatric Clinics of North America
SN - 0193-953X
IS - 2
ER -