Background and rationale for the sequenced treatment alternatives to relieve depression (STAR*D) study

Maurizio Fava, A. John Rush, Madhukar H. Trivedi, Andrew A. Nierenberg, Michael E. Thase, Harold A. Sackeim, Frederic M. Quitkin, Steven Wisniewski, Philip W. Lavori, Jerrold F. Rosenbaum, David J. Kupfer

Research output: Contribution to journalReview articlepeer-review

459 Scopus citations

Abstract

Sequenced Treatment Alternatives to Relieve Depression (STAR*D) attempts to fill in major clinical information gaps and to evaluate the theoretical principles and clinical beliefs that currently guide pharmacotherapy of major depressive disorder. The study is conducted in representative participant groups and settings using clinical management tools that easily can be applied in daily practice. Outcomes include clinical outcomes and health care utilization and cost estimates. Research findings should be immediately applicable to, and easily implemented in, the daily primary and specialty care practices. This article provides the overall rationale for STAR*D and details the rationale for key design, measurement, and analytic features of the study.

Original languageEnglish (US)
Pages (from-to)457-494
Number of pages38
JournalPsychiatric Clinics of North America
Volume26
Issue number2
DOIs
StatePublished - Jun 2003

ASJC Scopus subject areas

  • Psychiatry and Mental health

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