Bacteria from diverse habitats colonize and compete in the mouse gut

Henning Seedorf, Nicholas W. Griffin, Vanessa K. Ridaura, Alejandro Reyes, Jiye Cheng, Federico E. Rey, Michelle I. Smith, Gabriel M. Simon, Rudolf H. Scheffrahn, Dagmar Woebken, Alfred M. Spormann, William Van Treuren, Luke K. Ursell, Megan Pirrung, Adam Robbins-Pianka, Brandi L. Cantarel, Vincent Lombard, Bernard Henrissat, Rob Knight, Jeffrey I. Gordon

Research output: Contribution to journalArticlepeer-review

195 Scopus citations

Abstract

To study how microbes establish themselves in a mammalian gut environment, we colonized germ-free mice with microbial communities from human, zebrafish, and termite guts, human skin and tongue, soil, and estuarine microbial mats. Bacteria from these foreign environments colonized and persisted in the mouse gut; their capacity to metabolize dietary and host carbohydrates and bile acids correlated with colonization success. Cohousing mice harboring these xenomicrobiota or a mouse cecal microbiota, along with germ-free "bystanders," revealed the success of particular bacterial taxa in invading guts with established communities and empty gut habitats. Unanticipated patterns of ecological succession were observed; for example, a soil-derived bacterium dominated even in the presence of bacteria from other gut communities (zebrafish and termite), and human-derived bacteria colonized germ-free bystander mice before mouse-derived organisms. This approach can be generalized to address a variety of mechanistic questions about succession, including succession in the context of microbiota-directed therapeutics.

Original languageEnglish (US)
Pages (from-to)253-266
Number of pages14
JournalCell
Volume159
Issue number2
DOIs
StatePublished - Oct 9 2014

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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