Bacterial Infections of the Central Nervous System: Pathogenesis, Pathophysiology and Clinical Aspects

Jeffrey M. Tessier; W. Michael Scheld

doi:10.1016/B978-0-12-397169-2.00096-2

Bacterial Infections of the Central Nervous System: Pathogenesis, Pathophysiology and Clinical Aspects

Jeffrey M. Tessier, W. Michael Scheld

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Scopus citations

Abstract

The central nervous system may be infected by a wide variety of bacteria, often as part of what is at first a bacteraemia but may later become a septicaemia, and sometimes as a result of extension from adjacent tissues. This chapter considers the pathophysiology of CNS bacterial infections and some of the host responses to these infections. In some cases an inadequate immune response may allow chronic infection to develop. Under other circumstances, notably meningitis, it is the host response that gives rise to tissue injury.

Original language	English (US)
Title of host publication	Molecular Medical Microbiology
Publisher	Elsevier
Pages	1693-1707
Number of pages	15
ISBN (Electronic)	9780123971692
ISBN (Print)	9780123977632
DOIs	https://doi.org/10.1016/B978-0-12-397169-2.00096-2
State	Published - Jan 1 2014
Externally published	Yes

Keywords

Abscess
Chemokine
Cytokine
Invasion
Meningitis
Neuroborreliosis
Neurosyphilis
PAMP (pathogen associated molecular pattern)
PRR (pattern recognition receptors)
Tuberculoma

ASJC Scopus subject areas

General Immunology and Microbiology
General Biochemistry, Genetics and Molecular Biology

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10.1016/B978-0-12-397169-2.00096-2

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abstract = "The central nervous system may be infected by a wide variety of bacteria, often as part of what is at first a bacteraemia but may later become a septicaemia, and sometimes as a result of extension from adjacent tissues. This chapter considers the pathophysiology of CNS bacterial infections and some of the host responses to these infections. In some cases an inadequate immune response may allow chronic infection to develop. Under other circumstances, notably meningitis, it is the host response that gives rise to tissue injury.",

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AB - The central nervous system may be infected by a wide variety of bacteria, often as part of what is at first a bacteraemia but may later become a septicaemia, and sometimes as a result of extension from adjacent tissues. This chapter considers the pathophysiology of CNS bacterial infections and some of the host responses to these infections. In some cases an inadequate immune response may allow chronic infection to develop. Under other circumstances, notably meningitis, it is the host response that gives rise to tissue injury.

KW - Abscess

KW - Chemokine

KW - Cytokine

KW - Invasion

KW - Meningitis

KW - Neuroborreliosis

KW - Neurosyphilis

KW - PAMP (pathogen associated molecular pattern)

KW - PRR (pattern recognition receptors)

KW - Tuberculoma

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BT - Molecular Medical Microbiology

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ER -

Bacterial Infections of the Central Nervous System: Pathogenesis, Pathophysiology and Clinical Aspects

Abstract

Keywords

ASJC Scopus subject areas

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