Bacterial Infections of the Central Nervous System: Pathogenesis, Pathophysiology and Clinical Aspects

Jeffrey M. Tessier, W. Michael Scheld

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The central nervous system may be infected by a wide variety of bacteria, often as part of what is at first a bacteraemia but may later become a septicaemia, and sometimes as a result of extension from adjacent tissues. This chapter considers the pathophysiology of CNS bacterial infections and some of the host responses to these infections. In some cases an inadequate immune response may allow chronic infection to develop. Under other circumstances, notably meningitis, it is the host response that gives rise to tissue injury.

Original languageEnglish (US)
Title of host publicationMolecular Medical Microbiology
Subtitle of host publicationSecond Edition
PublisherElsevier Ltd.
Pages1693-1707
Number of pages15
Volume3
ISBN (Electronic)9780123971692
ISBN (Print)9780126775303
DOIs
StatePublished - Nov 26 2014
Externally publishedYes

Keywords

  • Abscess
  • Chemokine
  • Cytokine
  • Invasion
  • Meningitis
  • Neuroborreliosis
  • Neurosyphilis
  • PAMP (pathogen associated molecular pattern)
  • PRR (pattern recognition receptors)
  • Tuberculoma

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Tessier, J. M., & Scheld, W. M. (2014). Bacterial Infections of the Central Nervous System: Pathogenesis, Pathophysiology and Clinical Aspects. In Molecular Medical Microbiology: Second Edition (Vol. 3, pp. 1693-1707). Elsevier Ltd.. https://doi.org/10.1016/B978-0-12-397169-2.00096-2