Bacterial interference in upper respiratory tract infections: A systematic review

Michael Benninger, Itzhak Brook, Joel M. Bernstein, Janet R. Casey, Kristian Roos, Bradley Marple, Judith R. Farrar

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Published definitions of bacterial interference (BI) differ, some focusing on changes in the normal flora and others on changes in subsequent infection. A need for consensus was identified at a roundtable discussion of BI in upper respiratory tract infections (URTI). We conducted a systematic review of the available data to justify a consensus definition of BI specific to URTI as "a dynamic, antagonistic interaction between at least 2 organisms that affects the life cycle of each, changes the microenvironment, and alters the organisms' colonization, invasiveness, and ability to affect the health of the host." Methods: Continued communication among the faculty postroundtable was used to identify and refine the search criteria to (1) in vitro and in vivo studies assessing bacterial URTI, (2) BI evaluated by response to treatment of URTI with antimicrobial agents, and (3) bacterial function in relation to interactions between normal (nonpathogenic) and pathological flora. The criteria were applied to systematic searches of MEDLINE (1950 onward), EMBASE (1974 onward), and the Cochrane Library (2007). Results: Twenty-nine studies met the inclusion criteria, most focused on children with recurrent infections. Qualitative analysis supports the consensus definition. Interfering organisms affected the life cycle of test pathogens and inhibited their colonization, invasiveness, and health outcomes. Data were insufficient for statistical analysis. Conclusion: Interactions between interfering organisms and potential pathogens isolated from the same host can alter response to infection and treatment. More studies are needed, particularly in adults, to understand the role of interfering organisms, the influence of antibiotics, and the potential for recolonization posttreatment.

Original languageEnglish (US)
Pages (from-to)82-88
Number of pages7
JournalAmerican Journal of Rhinology and Allergy
Volume25
Issue number2
DOIs
StatePublished - Mar 2011

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Antibiosis
Respiratory Tract Infections
Life Cycle Stages
Infection
Aptitude
Health
Anti-Infective Agents
MEDLINE
Libraries
Consensus
Communication
Anti-Bacterial Agents
Therapeutics

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Immunology and Allergy

Cite this

Bacterial interference in upper respiratory tract infections : A systematic review. / Benninger, Michael; Brook, Itzhak; Bernstein, Joel M.; Casey, Janet R.; Roos, Kristian; Marple, Bradley; Farrar, Judith R.

In: American Journal of Rhinology and Allergy, Vol. 25, No. 2, 03.2011, p. 82-88.

Research output: Contribution to journalArticle

Benninger, Michael ; Brook, Itzhak ; Bernstein, Joel M. ; Casey, Janet R. ; Roos, Kristian ; Marple, Bradley ; Farrar, Judith R. / Bacterial interference in upper respiratory tract infections : A systematic review. In: American Journal of Rhinology and Allergy. 2011 ; Vol. 25, No. 2. pp. 82-88.
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