Bacterial meningitis in children

Xavier Sáez-Llorens, George H. McCracken

Research output: Contribution to journalArticle

312 Citations (Scopus)

Abstract

This review comprises aspects of the epidemiology, microbiology, pathophysiology, clinical manifestations, diagnosis, management, prognosis, and prevention of bacterial meningitis, with emphasis on the paediatric population. The beginning of this millennium has witnessed the virtual disappearance of Haemophilus invasive disease in some countries, emergence of pneumococcal strains that are resistant to multiple antibiotics, isolation of pneumococci with tolerance to vancomycin, outbreaks and clusters of meningococcal meningitis in several geographical areas, and intense research in development of effective conjugate pneumococcal and meningococcal vaccines. Bacterial meningitis has become an uncommon disease in the developed world. Unfortunately, because of limited economic resources and poor living conditions, many developing countries are still affected by the devastating consequences of this life-threatening systemic infection. Basic and clinical research is needed to discover new antimicrobial and anti-inflammatory agents to improve outcome from disease. Novel strategies are needed to distribute and implement effective vaccines worldwide to prevent bacterial meningitis.

Original languageEnglish (US)
Pages (from-to)2139-2148
Number of pages10
JournalLancet
Volume361
Issue number9375
DOIs
StatePublished - Jun 21 2003

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Bacterial Meningitides
Meningococcal Vaccines
Meningococcal Meningitis
Haemophilus
Conjugate Vaccines
Pneumococcal Vaccines
Social Conditions
Vancomycin
Streptococcus pneumoniae
Microbiology
Research
Developing Countries
Disease Outbreaks
Epidemiology
Anti-Inflammatory Agents
Vaccines
Economics
Pediatrics
Anti-Bacterial Agents
Infection

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Bacterial meningitis in children. / Sáez-Llorens, Xavier; McCracken, George H.

In: Lancet, Vol. 361, No. 9375, 21.06.2003, p. 2139-2148.

Research output: Contribution to journalArticle

Sáez-Llorens, Xavier ; McCracken, George H. / Bacterial meningitis in children. In: Lancet. 2003 ; Vol. 361, No. 9375. pp. 2139-2148.
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