Bacterial reductionism: Host thiols enhance virulence

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Intracellular bacteria exploit host cytosolic signals to upregulate virulence genes. In this issue of Cell Host and Microbe, Wong et al. (2015) show that Burkholderia pseudomallei senses host cytosolic glutathione, a low-molecular-weight thiol, through the membrane-bound histidine sensor kinase VirA, highlighting the importance of inter-kingdom signaling in bacterial pathogenesis.

Original languageEnglish (US)
Pages (from-to)7-8
Number of pages2
JournalCell Host and Microbe
Volume18
Issue number1
DOIs
StatePublished - 2015

Fingerprint

Burkholderia pseudomallei
Sulfhydryl Compounds
Glutathione
Virulence
Up-Regulation
Molecular Weight
Bacteria
Membranes
Genes
Histidine Kinase

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Cancer Research
  • Molecular Biology

Cite this

Bacterial reductionism : Host thiols enhance virulence. / Sperandio, Vanessa.

In: Cell Host and Microbe, Vol. 18, No. 1, 2015, p. 7-8.

Research output: Contribution to journalArticle

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