Bacterial reductionism: Host thiols enhance virulence

Vanessa Sperandio

Research output: Contribution to journalShort surveypeer-review

1 Scopus citations


Intracellular bacteria exploit host cytosolic signals to upregulate virulence genes. In this issue of Cell Host and Microbe, Wong et al. (2015) show that Burkholderia pseudomallei senses host cytosolic glutathione, a low-molecular-weight thiol, through the membrane-bound histidine sensor kinase VirA, highlighting the importance of inter-kingdom signaling in bacterial pathogenesis.

Original languageEnglish (US)
Pages (from-to)7-8
Number of pages2
JournalCell Host and Microbe
Issue number1
StatePublished - 2015

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Virology


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