Bactericidal activity of antiseptics against methicillin-resistant Staphylococcus aureus

C. E. Haley, M. Marling-Cason, J. W. Smith, J. P. Luby, P. A. Mackowiak

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

Various commonly used antiseptics were tested against three strains of methicillin-resistant Staphylococcus aureus (MRSA) at stock strength and in serial 10-fold dilutions. The stock solutions of 4% chlorhexidine gluconate-alcohol (Hibiclens), 1% p-chloro-m-xylenol (Acute-Kare), and 3% hexachlorophene (Phisohex) produced 2-log reductions of MRSA after a 15-s exposure, but even after 240 s, these solutions failed to kill all the MRSA. Povidone-iodine (Betadine) solution was maximally effected at the 1:100 dilution, killing all the MRSA within 15 s; other dilutions were less effective, though each killed the MRSA within 120 s. Similar results were obtained with three different strains of methicillin-susceptible S. aureus. Thus, of the four most commonly used antiseptics, providone-iodine, when diluted 1:100, was the most rapidly bactericidal against both MRSA and methicillin-susceptible S. aureus.

Original languageEnglish (US)
Pages (from-to)991-992
Number of pages2
JournalJournal of Clinical Microbiology
Volume21
Issue number6
StatePublished - 1985

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Local Anti-Infective Agents
Methicillin-Resistant Staphylococcus aureus
Povidone-Iodine
Methicillin
Staphylococcus aureus
Hexachlorophene
Triclosan
Iodine
Alcohols

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

Cite this

Haley, C. E., Marling-Cason, M., Smith, J. W., Luby, J. P., & Mackowiak, P. A. (1985). Bactericidal activity of antiseptics against methicillin-resistant Staphylococcus aureus. Journal of Clinical Microbiology, 21(6), 991-992.

Bactericidal activity of antiseptics against methicillin-resistant Staphylococcus aureus. / Haley, C. E.; Marling-Cason, M.; Smith, J. W.; Luby, J. P.; Mackowiak, P. A.

In: Journal of Clinical Microbiology, Vol. 21, No. 6, 1985, p. 991-992.

Research output: Contribution to journalArticle

Haley, CE, Marling-Cason, M, Smith, JW, Luby, JP & Mackowiak, PA 1985, 'Bactericidal activity of antiseptics against methicillin-resistant Staphylococcus aureus', Journal of Clinical Microbiology, vol. 21, no. 6, pp. 991-992.
Haley, C. E. ; Marling-Cason, M. ; Smith, J. W. ; Luby, J. P. ; Mackowiak, P. A. / Bactericidal activity of antiseptics against methicillin-resistant Staphylococcus aureus. In: Journal of Clinical Microbiology. 1985 ; Vol. 21, No. 6. pp. 991-992.
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