Bacteriological efficacy of nafcillin and vancomycin alone or combined with rifampicin or amikacin in experimental meningitis due to methicillin-susceptible or -resistant Staphylococcus aureus

K. Sato, T. Y. Lin, L. Weintrub, K. Olsen, G. H. McCracken

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Although meningitis due to Staphylococcus aureus is uncommon today in infants and children, it remains an important pathogen, particularly in catheter-associated infections. In cerebrospinal fluid (CSF) shunt infections, S. aureus accounts for approximately one quarter of infections. Optimal antimicrobial therapy of that infection and of other infections of the central nervous system due to S. aureus is problematic, particularly for disease due to methicillin (DMPPC)-resistant strains. An experimental meningitis model of staphylococcal meningitis was established by others to evaluate the pharmacokinetics of antistaphylococcal drugs, but comparative bacteriological efficacy studies have not been performed. The purpose of this study was to determine the pharmacokinetics and bacteriological effect of nafcillin (NFPC) or vancomycin (VCM) alone or in combination with rifampicin (RFP) or of amikacin (AMK) alone or combined with VCM in experimental meningitis due to a DMPPC-susceptible S. aureus (MSSA) or DMPPC-resistant S. aureus (MRSA) strain.

Original languageEnglish (US)
Pages (from-to)2155-2162
Number of pages8
JournalJapanese Journal of Antibiotics
Volume38
Issue number8
StatePublished - 1985

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Nafcillin
Methicillin
Amikacin
Vancomycin
Rifampin
Meningitis
Staphylococcus aureus
Pharmacokinetics
Infection
Cerebrospinal Fluid Shunts
Catheter-Related Infections
Central Nervous System Infections
Methicillin Resistance
Methicillin-Resistant Staphylococcus aureus
Theoretical Models
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine

Cite this

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title = "Bacteriological efficacy of nafcillin and vancomycin alone or combined with rifampicin or amikacin in experimental meningitis due to methicillin-susceptible or -resistant Staphylococcus aureus",
abstract = "Although meningitis due to Staphylococcus aureus is uncommon today in infants and children, it remains an important pathogen, particularly in catheter-associated infections. In cerebrospinal fluid (CSF) shunt infections, S. aureus accounts for approximately one quarter of infections. Optimal antimicrobial therapy of that infection and of other infections of the central nervous system due to S. aureus is problematic, particularly for disease due to methicillin (DMPPC)-resistant strains. An experimental meningitis model of staphylococcal meningitis was established by others to evaluate the pharmacokinetics of antistaphylococcal drugs, but comparative bacteriological efficacy studies have not been performed. The purpose of this study was to determine the pharmacokinetics and bacteriological effect of nafcillin (NFPC) or vancomycin (VCM) alone or in combination with rifampicin (RFP) or of amikacin (AMK) alone or combined with VCM in experimental meningitis due to a DMPPC-susceptible S. aureus (MSSA) or DMPPC-resistant S. aureus (MRSA) strain.",
author = "K. Sato and Lin, {T. Y.} and L. Weintrub and K. Olsen and McCracken, {G. H.}",
year = "1985",
language = "English (US)",
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pages = "2155--2162",
journal = "The Journal of antibiotics. Ser. B",
issn = "0368-2781",
publisher = "Japan Antibiotics Research Association",
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TY - JOUR

T1 - Bacteriological efficacy of nafcillin and vancomycin alone or combined with rifampicin or amikacin in experimental meningitis due to methicillin-susceptible or -resistant Staphylococcus aureus

AU - Sato, K.

AU - Lin, T. Y.

AU - Weintrub, L.

AU - Olsen, K.

AU - McCracken, G. H.

PY - 1985

Y1 - 1985

N2 - Although meningitis due to Staphylococcus aureus is uncommon today in infants and children, it remains an important pathogen, particularly in catheter-associated infections. In cerebrospinal fluid (CSF) shunt infections, S. aureus accounts for approximately one quarter of infections. Optimal antimicrobial therapy of that infection and of other infections of the central nervous system due to S. aureus is problematic, particularly for disease due to methicillin (DMPPC)-resistant strains. An experimental meningitis model of staphylococcal meningitis was established by others to evaluate the pharmacokinetics of antistaphylococcal drugs, but comparative bacteriological efficacy studies have not been performed. The purpose of this study was to determine the pharmacokinetics and bacteriological effect of nafcillin (NFPC) or vancomycin (VCM) alone or in combination with rifampicin (RFP) or of amikacin (AMK) alone or combined with VCM in experimental meningitis due to a DMPPC-susceptible S. aureus (MSSA) or DMPPC-resistant S. aureus (MRSA) strain.

AB - Although meningitis due to Staphylococcus aureus is uncommon today in infants and children, it remains an important pathogen, particularly in catheter-associated infections. In cerebrospinal fluid (CSF) shunt infections, S. aureus accounts for approximately one quarter of infections. Optimal antimicrobial therapy of that infection and of other infections of the central nervous system due to S. aureus is problematic, particularly for disease due to methicillin (DMPPC)-resistant strains. An experimental meningitis model of staphylococcal meningitis was established by others to evaluate the pharmacokinetics of antistaphylococcal drugs, but comparative bacteriological efficacy studies have not been performed. The purpose of this study was to determine the pharmacokinetics and bacteriological effect of nafcillin (NFPC) or vancomycin (VCM) alone or in combination with rifampicin (RFP) or of amikacin (AMK) alone or combined with VCM in experimental meningitis due to a DMPPC-susceptible S. aureus (MSSA) or DMPPC-resistant S. aureus (MRSA) strain.

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VL - 38

SP - 2155

EP - 2162

JO - The Journal of antibiotics. Ser. B

JF - The Journal of antibiotics. Ser. B

SN - 0368-2781

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