Banff 2013 meeting report: Inclusion of C4d-negative antibody-mediated rejection and antibody-associated arterial lesions

M. Haas, B. Sis, L. C. Racusen, K. Solez, D. Glotz, R. B. Colvin, M. C.R. Castro, D. S.R. David, E. David-Neto, S. M. Bagnasco, L. C. Cendales, L. D. Cornell, A. J. Demetris, C. B. Drachenberg, C. F. Farver, A. B. Farris, I. W. Gibson, E. Kraus, H. Liapis, A. LoupyV. Nickeleit, P. Randhawa, E. R. Rodriguez, D. Rush, R. N. Smith, C. D. Tan, W. D. Wallace, M. Mengel, Serena M. Bagnasco, Gerald Berry, Marie Budev, Linda C. Cendales, Monica Colvin-Adams, Robert B. Colvin, Lynn D. Cornell, Anthony J. Demetris, Cinthia B. Drachenberg, A. Brad Farris, Carol F. Farver, Sandy Feng, Max Fischer, Agnes Fogo, Vijay Gorantla, Mark Haas, Danniele Holanda, Stanley Jordan, Christina Kaufman, Stuart J. Knechtle, Tomasz Kozlowski, Sheri Krams, Edward Kraus, Helen Liapis, John Lunz, Roslyn B. Mannon, Kenneth Newell, Volker Nickeleit, Jon Odorico, Jaqueline O’Leary, John Papadimitriou, Lorraine C. Racusen, Parmjeet Randhawa, Nancy Reinsmoen, E. Rene Rodriguez, Minnie Sarwal, Janet Scheel, Surya Seshan, Chandra Smart, Rex Neal Smith, Carmela D. Tan, Dolly B. Tyan, W. Dean Wallace, Adriana Zeevi, Oyedele Adeyi, Patricia Campbell, Ian W. Gibson, Luis Hidalgo, Michael Mengel, Banu Sis, Kim Solez, Venancio Avancini, Maria Cristina R. Castro, Daisa S.R. David, Elias DavidNeto, Marcello Franco, Maria Gerbase Lima, Denise Maria Malheiros, Irene Noronha, Erika Rangel, Helio Tedesco Silva, Christopher Bellamy, Martin Goddard, Stefan Hubscher, Desley Neil, Candice Roufosse, Steven Sacks, Alberto Sánchez-Fueyo, Denis Glotz, Alexandre Loupy, Emmanuel Morelon, Hanneke de Kort, Annette Gouw, Joseph Grinyó, Hironori Haga, Erik Larsson, Brian Nankivell, Norma Ofelia Uribe, Juan Pablo Cordoba

Research output: Contribution to journalArticle

787 Scopus citations

Abstract

The 12th Banff Conference on Allograft Pathology was held in Comandatuba, Brazil, from August 19-23, 2013, and was preceded by a 2-day Latin American Symposium on Transplant Immunobiology and Immunopathology. The meeting was highlighted by the presentation of the findings of several working groups formed at the 2009 and 2011 Banff meetings to: (1) establish consensus criteria for diagnosing antibody-mediated rejection (ABMR) in the presence and absence of detectable C4d deposition; (2) develop consensus definitions and thresholds for glomerulitis (g score) and chronic glomerulopathy (cg score), associated with improved inter-observer agreement and correlation with clinical, molecular and serological data; (3) determine whether isolated lesions of intimal arteritis ("isolated v") represent acute rejection similar to intimal arteritis in the presence of tubulointerstitial inflammation; (4) compare different methodologies for evaluating interstitial fibrosis and for performing/evaluating implantation biopsies of renal allografts with regard to reproducibility and prediction of subsequent graft function; and (5) define clinically and prognostically significant morphologic criteria for subclassifying polyoma virus nephropathy. The key outcome of the 2013 conference is defining criteria for diagnosis of C4d-negative ABMR and respective modification of the Banff classification. In addition, three new Banff Working Groups were initiated. The 2013 Banff Transplant Conference defines revised, consensus criteria for acute/active and chronic, active antibody-mediated rejection in renal allograft biopsies, criteria that include C4d-negative antibody-mediated rejection and antibody-associated arterial lesions. Also see comprehensive review by Djamali et al on page 255.

Original languageEnglish (US)
Pages (from-to)272-283
Number of pages12
JournalAmerican Journal of Transplantation
Volume14
Issue number2
DOIs
StatePublished - Feb 1 2014

    Fingerprint

Keywords

  • Acute allograft rejection
  • Banff schema
  • antibody-mediated rejection
  • cardiac allograft
  • chronic allograft rejection
  • complement C4d
  • composite tissue allograft
  • donor-specific antibodies
  • liver allograft
  • lung transplantation
  • pancreas allograft
  • renal transplantation
  • transplant biopsy
  • transplant glomerulopathy
  • transplant pathology

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

Cite this

Haas, M., Sis, B., Racusen, L. C., Solez, K., Glotz, D., Colvin, R. B., Castro, M. C. R., David, D. S. R., David-Neto, E., Bagnasco, S. M., Cendales, L. C., Cornell, L. D., Demetris, A. J., Drachenberg, C. B., Farver, C. F., Farris, A. B., Gibson, I. W., Kraus, E., Liapis, H., ... Cordoba, J. P. (2014). Banff 2013 meeting report: Inclusion of C4d-negative antibody-mediated rejection and antibody-associated arterial lesions. American Journal of Transplantation, 14(2), 272-283. https://doi.org/10.1111/ajt.12590