@article{cd8c30276cb94cfaa30800d8f2b22147,
title = "BAP1: A novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression",
abstract = "We have identified a novel protein, BAP1, which binds to the RING finger domain of the Breast/Ovarian Cancer Susceptibility Gene product, BRCA1. BAP1 is a nuclear-localized, ubiquitin carboxy-terminal hydrolase, suggesting that deubiquitinating enzymes may play a role in BRCA1 function. BAP1 binds to the wild-type BRCA1-RING finger, but not to germline mutants of the BRCA1-RING finger found in breast cancer kindreds. BAP1 and BRCA1 are temporally and spatially co-expressed during murine breast development and remodeling, and show overlapping patterns of subnuclear distribution. BAP1 resides on human chromosome 3p21.3; intragenic homozgyous rearrangements and deletions of BAP1 have been found in lung carcinoma cell lines. BAP1 enhances BRCA1-mediated inhibition of breast cancer cell growth and is the first nuclear-localized ubiquitin carboxy-terminal hydrolase to be identified. BAP1 may be a new tumor suppressor gene which functions in the BRCA1 growth control pathway.",
keywords = "BRCA1, Chromosome 3p21.3, RING finger, Ubiquitin hydrolase",
author = "Jensen, {David E.} and Monja Proctor and Marquis, {Sandra T.} and Gardner, {Heather Perry} and Ha, {Seung I.} and Chodosh, {Lewis A.} and Ishov, {Alexander M.} and Niels Tommerup and Henrik Vissing and Yoshitaka Sekido and John Minna and Anna Borodovsky and Schultz, {David C.} and Wilkinson, {Keith D.} and Maul, {Gerd G.} and Nickolai Barlev and Berger, {Shelley L.} and Prendergast, {George C.} and Rauscher, {Frank J.}",
note = "Funding Information: We thank E Koonin (NIH/NCBI) for DNA sequence analysis and suggesting a potential gap in our original cDNA clone; Dr R Baer for supplying an anti-BAP1 antibody which allowed us to verify a variety of results; Drs B Weber, F Couch, W Fredericks and J Friedman for their many helpful discussions and the technical assistance of Jing Wang, Bodil Olsen and Winni Pedersen. JM is a recipient of an NCI P50 Lung Cancer SPORE grant. KDW is supported by NIH grant GM30308. NT is supported by The Danish Cancer Society. The Danish Environment Research Programme, The Danish Biotechnological Research and Development Programme, The Danish Research Center for Growth and Regeneration, The Novo Nordisk Foundation, and The Aage Bang Foundation. LAC is a Charles E Culpeper Medical Scholar and is supported by the Charles E Culpeper Foundation and NCI grant CA71513. GCP is supported by an ACS Junior Faculty Award and is a Pew Scholar in the Biomedical Sciences. FJR is supported by National Institutes of Health grants: Core grant CA10815, DK 49210, GM 54220, DAMD17-96-6141, ACS NP-954, the Irving A Hansen Memorial Foundation, the Mary A Rumsey Memorial Foundation and the Pew Scholars Program in the Biomedical Sciences. DEJ is a Susan G Koman Breast Cancer Foundation Postdoctoral Fellow. GenBank accession No. AF045581.",
year = "1998",
month = mar,
day = "5",
doi = "10.1038/sj.onc.1201861",
language = "English (US)",
volume = "16",
pages = "1097--1112",
journal = "Oncogene",
issn = "0950-9232",
publisher = "Nature Publishing Group",
number = "9",
}