Barrett's Esophagus

S. J. Spechler, R. K. Goyal

Research output: Contribution to journalReview articlepeer-review

710 Scopus citations

Abstract

BARRETT'S esophagus is a condition in which the squamous mucosa that normally lines the distal esophagus is replaced by a columnar epithelium resembling that in the stomach and intestines. This aberrant epithelium may be the site of esophageal ulceration, stricture, and adenocarcinoma. Early misconceptions and ongoing controversies regarding the definition, pathogenesis, and clinical features of Barrett's esophagus have resulted in persistent confusion about the disorder. Recent studies have clarified some of these issues substantially. The purpose of this report is to review critically some of the controversies about Barrett's esophagus and to describe the recent advances in our understanding of.

Original languageEnglish (US)
Pages (from-to)362-371
Number of pages10
JournalNew England Journal of Medicine
Volume315
Issue number6
DOIs
StatePublished - Aug 7 1986

ASJC Scopus subject areas

  • Medicine(all)

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