Barrett's esophagus and esophageal adenocarcinoma: Pathogenesis, diagnosis, and therapy

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Gastric juice that refluxes into the esophagus can injure esophageal squamous epithelium. When the injury heals through a metaplastic process in which an abnormal columnar epithelium replaces the injured squamous one, the resulting condition is called Barrett's esophagus. Gastroesophageal reflux disease and Barrett's esophagus are the most important risk factors for esophageal adenocarcinoma. This article examines such issues as the treatment, endoscopic surveillance, and chemoprevention of Barrett's esophagus. Also included are published guidelines and recommendations.

Original languageEnglish (US)
Pages (from-to)1423-1445
Number of pages23
JournalMedical Clinics of North America
Volume86
Issue number6
DOIs
StatePublished - Nov 2002

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Barrett Esophagus
Adenocarcinoma
Epithelium
Gastric Juice
Chemoprevention
Gastroesophageal Reflux
Esophagus
Therapeutics
Guidelines
Wounds and Injuries

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Barrett's esophagus and esophageal adenocarcinoma : Pathogenesis, diagnosis, and therapy. / Spechler, Stuart Jon.

In: Medical Clinics of North America, Vol. 86, No. 6, 11.2002, p. 1423-1445.

Research output: Contribution to journalArticle

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