TY - JOUR
T1 - Barrett's esophagus and esophageal adenocarcinoma
T2 - Pathogenesis, diagnosis, and therapy
AU - Spechler, Stuart Jon
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2002/11
Y1 - 2002/11
N2 - Gastric juice that refluxes into the esophagus can injure esophageal squamous epithelium. When the injury heals through a metaplastic process in which an abnormal columnar epithelium replaces the injured squamous one, the resulting condition is called Barrett's esophagus. Gastroesophageal reflux disease and Barrett's esophagus are the most important risk factors for esophageal adenocarcinoma. This article examines such issues as the treatment, endoscopic surveillance, and chemoprevention of Barrett's esophagus. Also included are published guidelines and recommendations.
AB - Gastric juice that refluxes into the esophagus can injure esophageal squamous epithelium. When the injury heals through a metaplastic process in which an abnormal columnar epithelium replaces the injured squamous one, the resulting condition is called Barrett's esophagus. Gastroesophageal reflux disease and Barrett's esophagus are the most important risk factors for esophageal adenocarcinoma. This article examines such issues as the treatment, endoscopic surveillance, and chemoprevention of Barrett's esophagus. Also included are published guidelines and recommendations.
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U2 - 10.1016/S0025-7125(02)00082-2
DO - 10.1016/S0025-7125(02)00082-2
M3 - Review article
C2 - 12510459
AN - SCOPUS:0036867761
SN - 0025-7125
VL - 86
SP - 1423
EP - 1445
JO - Medical Clinics of North America
JF - Medical Clinics of North America
IS - 6
ER -