TY - JOUR
T1 - Barrett's esophagus
T2 - Chemoprevention
AU - Souza, Rhonda F.
AU - Spechler, Stuart J.
N1 - Funding Information:
Supported by the Office of Medical Research, Department of Veteran's Affairs, Dallas, TX, the Glaxo Wellcome Institute for Digestive Health, and the National Institutes of Health DK63621 (R.F. Souza).
PY - 2003/7
Y1 - 2003/7
N2 - The clinical applicability of the experimental data discussed previously remains questionable, and results of clinical studies on chemoprevention in Barrett's esophagus are needed. The utility of selectively targeting acid exposure, ODC, and COX-2 is not clear, and elucidation of that role will be facilitated by a better understanding of the contribution of these factors in the development of Barrett's cancers. The insights already gained into the basic mechanisms of acid exposure, ODC, and COX-2 in the pathogenesis of Barrett's esophagus and esophageal adenocarcinoma hold promise for the development of future therapies aimed at these molecular targets and their signaling pathways. In preclinical studies, the ability of COX-2 selective NSAIDs and DFMO to inhibit carcinogenesis is encouraging. Results of well-designed, prospective clinical studies, however, are still needed to establish the efficacy of potent acid suppression, COX-2 inhibitors, and DFMO in the prevention of this malignancy.
AB - The clinical applicability of the experimental data discussed previously remains questionable, and results of clinical studies on chemoprevention in Barrett's esophagus are needed. The utility of selectively targeting acid exposure, ODC, and COX-2 is not clear, and elucidation of that role will be facilitated by a better understanding of the contribution of these factors in the development of Barrett's cancers. The insights already gained into the basic mechanisms of acid exposure, ODC, and COX-2 in the pathogenesis of Barrett's esophagus and esophageal adenocarcinoma hold promise for the development of future therapies aimed at these molecular targets and their signaling pathways. In preclinical studies, the ability of COX-2 selective NSAIDs and DFMO to inhibit carcinogenesis is encouraging. Results of well-designed, prospective clinical studies, however, are still needed to establish the efficacy of potent acid suppression, COX-2 inhibitors, and DFMO in the prevention of this malignancy.
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U2 - 10.1016/S1052-5157(03)00039-4
DO - 10.1016/S1052-5157(03)00039-4
M3 - Review article
C2 - 14629099
AN - SCOPUS:0042817870
SN - 1052-5157
VL - 13
SP - 419
EP - 432
JO - Gastrointestinal Endoscopy Clinics of North America
JF - Gastrointestinal Endoscopy Clinics of North America
IS - 3
ER -