TY - JOUR
T1 - Basal-like and triple-negative breast cancers. Searching for positives among many negatives
AU - Alluri, Prasanna
AU - Newman, Lisa A.
N1 - Funding Information:
Dr Alluri was partly supported by the National Institutes of Health (T32 CA009672).
PY - 2014/7
Y1 - 2014/7
N2 - Triple-negative breast cancers (TNBC) are defined by their failure to express the estrogen receptor, progesterone receptor, and HER2/. neu protein markers. This basic feature is clinically relevant because it indicates that these cancers cannot be managed with endocrine or anti-HER2 systemic therapies. Furthermore, most TNBC cases are also characterized as being of the genetically defined basal subtype, which is an inherently and biologically more aggressive pattern of disease. The two terms, however, are not synonymous, and some TNBC cases are prognostically more favorable. TNBC differs from non-TNBC in risk-factor profile, pattern, and rate of metastatic spread.
AB - Triple-negative breast cancers (TNBC) are defined by their failure to express the estrogen receptor, progesterone receptor, and HER2/. neu protein markers. This basic feature is clinically relevant because it indicates that these cancers cannot be managed with endocrine or anti-HER2 systemic therapies. Furthermore, most TNBC cases are also characterized as being of the genetically defined basal subtype, which is an inherently and biologically more aggressive pattern of disease. The two terms, however, are not synonymous, and some TNBC cases are prognostically more favorable. TNBC differs from non-TNBC in risk-factor profile, pattern, and rate of metastatic spread.
KW - Basal breast cancer
KW - Breast cancer subtypes
KW - Triple-negative breast cancer
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U2 - 10.1016/j.soc.2014.03.003
DO - 10.1016/j.soc.2014.03.003
M3 - Review article
C2 - 24882351
AN - SCOPUS:84901586809
SN - 1055-3207
VL - 23
SP - 567
EP - 577
JO - Surgical Oncology Clinics of North America
JF - Surgical Oncology Clinics of North America
IS - 3
ER -