Basal-like and triple-negative breast cancers. Searching for positives among many negatives

Prasanna Alluri, Lisa A. Newman

Research output: Contribution to journalReview article

41 Scopus citations

Abstract

Triple-negative breast cancers (TNBC) are defined by their failure to express the estrogen receptor, progesterone receptor, and HER2/. neu protein markers. This basic feature is clinically relevant because it indicates that these cancers cannot be managed with endocrine or anti-HER2 systemic therapies. Furthermore, most TNBC cases are also characterized as being of the genetically defined basal subtype, which is an inherently and biologically more aggressive pattern of disease. The two terms, however, are not synonymous, and some TNBC cases are prognostically more favorable. TNBC differs from non-TNBC in risk-factor profile, pattern, and rate of metastatic spread.

Original languageEnglish (US)
Pages (from-to)567-577
Number of pages11
JournalSurgical Oncology Clinics of North America
Volume23
Issue number3
DOIs
StatePublished - Jul 2014

Keywords

  • Basal breast cancer
  • Breast cancer subtypes
  • Triple-negative breast cancer

ASJC Scopus subject areas

  • Surgery
  • Oncology

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