Baseline characteristics in the Avoiding Cardiovascular events through Combination therapy in Patients Living with Systolic Hypertension (ACCOMPLISH) trial: A hypertensive population at high cardiovascular risk

Michael A. Weber; George L. Bakris; Björn Dahlöf; Bertram Pitt; Eric Velazquez; Jitendra Gupte; Martin Lefkowitz; Allen Hester; Victor Shi; Matthew Weir; Sverre Kjeldsen; Barry Massie; Shawna Nesbitt; Elizabeth Ofili; Kenneth Jamerson

doi:10.1080/08037050701217643

Baseline characteristics in the Avoiding Cardiovascular events through Combination therapy in Patients Living with Systolic Hypertension (ACCOMPLISH) trial: A hypertensive population at high cardiovascular risk

Michael A. Weber, George L. Bakris, Björn Dahlöf, Bertram Pitt, Eric Velazquez, Jitendra Gupte, Martin Lefkowitz, Allen Hester, Victor Shi, Matthew Weir, Sverre Kjeldsen, Barry Massie, Shawna Nesbitt, Elizabeth Ofili, Kenneth Jamerson

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

ACCOMPLISH is the first trial designed to compare the effects on major fatal and non-fatal cardiovascular endpoints of two forms of antihypertensive combination therapy: benazepril plus hydrochlorothiazide and amlodipine plus benazepril in hypertensive patients at high cardiovascular risk. Enrollment for this trial is now complete and this report describes the clinical characteristics of the study cohort. Patients with hypertension and a previous history of cardiovascular events, strokes or diabetes mellitus were randomized to double-blind treatment with either of the two combination regimens. The data in this report detail the clinical history and demographic characteristics in patients immediately prior to randomization to study drugs. A total of 11,454 patients were randomized. Mean age (±SD) was 68.4±6.9 years, 60% were men, and 1360 (12%) were African American. Mean body mass index (BMI) was 31.0±6.3 kg/m². At study entry, 46% of patients had a history of acute coronary syndromes, coronary artery bypass grafts or percutaneous coronary interventions; 13% had a history of stroke. A history of diabetes mellitus was reported in 6928 (60%) of patients. Mean blood pressure at baseline (on prior hypertension therapy) was 145.4/80.0 Hg; only 38% of patients had a BP less than 140/90mmHg. Overall, 97% of patients had received previous antihypertensive treatment (74% on at least two drugs); 53% were on oral diabetes therapy or insulin, 68% on anti-lipid therapy and 63% on anti-platelet agents. In summary, the ACCOMPLISH trial has recruited hypertensive patients at high risk of cardiovascular morbidity and mortality. It is noteworthy that the mean BMI of 31 in this cohort is clearly above the accepted diagnostic criterion of obesity and that 60% of patients are diabetic, possibly reflecting secular trends in clinical disease.

Original language	English (US)
Pages (from-to)	13-19
Number of pages	7
Journal	Blood Pressure
Volume	16
Issue number	1
DOIs	https://doi.org/10.1080/08037050701217643
State	Published - 2007

Keywords

Cardiovascular outcomes
Clinical trials
Combination therapy
Hypertension

ASJC Scopus subject areas

Internal Medicine
Cardiology and Cardiovascular Medicine

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Weber, M. A., Bakris, G. L., Dahlöf, B., Pitt, B., Velazquez, E., Gupte, J., Lefkowitz, M., Hester, A., Shi, V., Weir, M., Kjeldsen, S., Massie, B., Nesbitt, S., Ofili, E., & Jamerson, K. (2007). Baseline characteristics in the Avoiding Cardiovascular events through Combination therapy in Patients Living with Systolic Hypertension (ACCOMPLISH) trial: A hypertensive population at high cardiovascular risk. Blood Pressure, 16(1), 13-19. https://doi.org/10.1080/08037050701217643

Baseline characteristics in the Avoiding Cardiovascular events through Combination therapy in Patients Living with Systolic Hypertension (ACCOMPLISH) trial: A hypertensive population at high cardiovascular risk. / Weber, Michael A.; Bakris, George L.; Dahlöf, Björn et al.
In: Blood Pressure, Vol. 16, No. 1, 2007, p. 13-19.

Research output: Contribution to journal › Article › peer-review

Weber, MA, Bakris, GL, Dahlöf, B, Pitt, B, Velazquez, E, Gupte, J, Lefkowitz, M, Hester, A, Shi, V, Weir, M, Kjeldsen, S, Massie, B, Nesbitt, S, Ofili, E & Jamerson, K 2007, 'Baseline characteristics in the Avoiding Cardiovascular events through Combination therapy in Patients Living with Systolic Hypertension (ACCOMPLISH) trial: A hypertensive population at high cardiovascular risk', Blood Pressure, vol. 16, no. 1, pp. 13-19. https://doi.org/10.1080/08037050701217643

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abstract = "ACCOMPLISH is the first trial designed to compare the effects on major fatal and non-fatal cardiovascular endpoints of two forms of antihypertensive combination therapy: benazepril plus hydrochlorothiazide and amlodipine plus benazepril in hypertensive patients at high cardiovascular risk. Enrollment for this trial is now complete and this report describes the clinical characteristics of the study cohort. Patients with hypertension and a previous history of cardiovascular events, strokes or diabetes mellitus were randomized to double-blind treatment with either of the two combination regimens. The data in this report detail the clinical history and demographic characteristics in patients immediately prior to randomization to study drugs. A total of 11,454 patients were randomized. Mean age (±SD) was 68.4±6.9 years, 60% were men, and 1360 (12%) were African American. Mean body mass index (BMI) was 31.0±6.3 kg/m2. At study entry, 46% of patients had a history of acute coronary syndromes, coronary artery bypass grafts or percutaneous coronary interventions; 13% had a history of stroke. A history of diabetes mellitus was reported in 6928 (60%) of patients. Mean blood pressure at baseline (on prior hypertension therapy) was 145.4/80.0 Hg; only 38% of patients had a BP less than 140/90mmHg. Overall, 97% of patients had received previous antihypertensive treatment (74% on at least two drugs); 53% were on oral diabetes therapy or insulin, 68% on anti-lipid therapy and 63% on anti-platelet agents. In summary, the ACCOMPLISH trial has recruited hypertensive patients at high risk of cardiovascular morbidity and mortality. It is noteworthy that the mean BMI of 31 in this cohort is clearly above the accepted diagnostic criterion of obesity and that 60% of patients are diabetic, possibly reflecting secular trends in clinical disease.",

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AU - Dahlöf, Björn

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AU - Velazquez, Eric

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AU - Hester, Allen

AU - Shi, Victor

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Baseline characteristics in the Avoiding Cardiovascular events through Combination therapy in Patients Living with Systolic Hypertension (ACCOMPLISH) trial: A hypertensive population at high cardiovascular risk

Abstract

Keywords

ASJC Scopus subject areas

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