Baseline characteristics of African Americans in the Systolic Blood Pressure Intervention Trial

Carolyn H. Still, Timothy E. Craven, Barry I. Freedman, Peter N. Van Buren, Kaycee M. Sink, Anthony A. Killeen, Jeffrey T. Bates, Alberta Bee, Gabriel Contreras, Suzanne Oparil, Carolyn M. Pedley, Barry M. Wall, Suzanne White, Delia M. Woods, Carlos J. Rodriguez, Jackson T. Wright

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The Systolic Blood Pressure Intervention Trial (SPRINT) will compare treatment to a systolic blood pressure goal of <120 mm Hg to treatment to the currently recommended goal of <140 mm Hg for effects on incident cardiovascular, renal, and neurologic outcomes including cognitive decline. The objectives of this analysis are to compare baseline characteristics of African American (AA) and non-AA SPRINT participants and explore factors associated with uncontrolled blood pressure (BP) by race. SPRINT enrolled 9361 hypertensive participants aged older than 50 years. This cross-sectional analysis examines sociodemographics, baseline characteristics, and study measures among AAs compared with non-AAs. AAs made up 31% of participants. AAs (compared with non-AAs) were younger and less frequently male, had less education, and were more likely uninsured or covered by Medicaid. In addition, AAs scored lower on the cognitive screening test when compared with non-AAs. Multivariate logistic regression analysis found BP control rates to <140/90 mm Hg were higher for AAs who were male, had higher number of chronic diseases, were on diuretic treatment, and had better medication adherence. SPRINT is well poised to examine the effects of systolic blood pressure targets on clinical outcomes as well as predictors influencing BP control in AAs.

Original languageEnglish (US)
Pages (from-to)670-679
Number of pages10
JournalJournal of the American Society of Hypertension
Volume9
Issue number9
DOIs
StatePublished - Sep 1 2015

Keywords

  • Cardiovascular disease
  • SPRINT
  • blacks
  • clinical trials
  • hypertension

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

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