Baseline clinical characteristics of patients recruited into the assessment of treatment with lisinopril and survival study

John G F Cleland, P. Armstrong, J. D. Horowitz, B. Massie, M. Packer, P. A. Poole-Wilson, L. Rydén

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Background: The beneficial effect of ACE inhibitors on mortality has been established in a series of trials. However, in clinical practice, ACE inhibitors are commonly administered in doses much lower than those shown to be effective in the landmark trials. Aims: This report describes the baseline characteristics of the patients recruited into the ATLAS study by age and gender sub-groups. Methods: The ATLAS study compared the effects of 'low' dose (2.5-5.0 mg/day) to 'high' dose (32.5-35.0 mg/day) lisinopril in a double-blind study of 3164 patients with moderate to severe heart failure and left ventricular ejection fraction < 30% during a mean follow-up period of 46 months. The primary end-point was all cause mortality and the principal secondary end-point a composite of all-cause hospitalisation or all-cause mortality. Results: Among patients with heart failure selected for the presence of left ventricular systolic function there were few differences among age groups or between genders. Older patients were not so heavy, were more likely to have ischaemic heart disease, hypertension and atrial fibrillation contributing to their heart failure and had a higher blood urea. Women were not so heavy as men. Age and gender had no major influence on mean ejection fraction or baseline treatment in the ATLAS study. Conclusions: Weight and renal function may alter the plasma concentration of any given dose of an ACE inhibitor. Potential interactions between dose of lisinopril, weight and renal function will be explored after the study is completed. (C) 1999 European Society of Cardiology.

Original languageEnglish (US)
Pages (from-to)73-79
Number of pages7
JournalEuropean Journal of Heart Failure
Volume1
Issue number1
DOIs
StatePublished - Mar 1 2000

Keywords

  • ACE inhibitors
  • Dose
  • Lisinopril
  • Patients with heart failure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Cleland, J. G. F., Armstrong, P., Horowitz, J. D., Massie, B., Packer, M., Poole-Wilson, P. A., & Rydén, L. (2000). Baseline clinical characteristics of patients recruited into the assessment of treatment with lisinopril and survival study. European Journal of Heart Failure, 1(1), 73-79. https://doi.org/10.1016/S1388-9842(98)00002-6