Basic considerations in simulated treatment planning for the Stanford Medical Pion Generator (SMPG)

David A. Pistenma, Gloria C. Li, Malcolm A. Bagshaw

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Recent interest in charged heavy particle irradiation is based upon expected improved local tumor control rates because of the greater precision in dose localization and the increased biological effectiveness of the high linear energy transfer ionization of particle beams in their stopping regions (Bragg peaks). A novel 60 beam cylindrical geometry pion spectrometer designed for a hospital-based pion therapy facility has been constructed at Stanford. In conjunction with the development and testing of the SMPG a program of simulated treatment planning is being conducted. This paper presents basic considerations in treatment planning for pions and other charged heavy particles. It also presents the status of simulated treatment planning calculations for the SMPG including a discussion of the principle of irradiation of hypothetical tumor volumes illustrated by examples of simplified treatment plans incorporating tissue density inhomogeneity corrections. Also presented are considerations for realistic simulated treatment planning calculations using computerized tomographic scan cross sections of actual patients and a conceptual plan for an integrated treatment planning and patient treatment system for the SMPG.

Original languageEnglish (US)
Pages (from-to)345-356
Number of pages12
JournalInternational journal of radiation oncology, biology, physics
Issue number3-4
StatePublished - Jan 1 1977


  • Pion radiotherapy
  • Tissue density inhomogeneity
  • Treatment planning

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research


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