Abstract
Limited therapeutic options impede the clinical outcome of triple-negative breast cancer (TNBC). Our recent study uncovered a novel signaling pathway implicating gamma-butyrobetaine hydroxylase 1 (BBOX1) in the control of cell growth in TNBC, via inositol 1, 4, 5-trisphosphate receptor type 3 (IP3R3) mediated calcium signaling which is essential for cellular energy metabolism.
Original language | English (US) |
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Article number | 1813526 |
Journal | Molecular and Cellular Oncology |
Volume | 7 |
Issue number | 6 |
DOIs | |
State | Published - Nov 1 2020 |
Keywords
- 2-OG dependent enzyme
- TNBC
- therapeutic target
ASJC Scopus subject areas
- Molecular Medicine
- Cancer Research