Abstract
Bcl-2 was the first identified cellular protein that functions as an oncogene by blocking apoptotic cell death. Beclin 1, the first identified mammalian autophagy gene product, is a haplo-insufficient tumor suppressor that was originally isolated as a Bcl-2-interacting protein. We recently showed that Bcl-2 negatively regulates Beclin 1-dependent autophagy and Beclin 1-dependent autophagic cell death. These findings raise the possibility that Bcl-2 family members may function as oncogenes not only by blocking apoptosis but also by blocking autophagy.
Original language | English (US) |
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Pages (from-to) | 2885-2888 |
Number of pages | 4 |
Journal | Cancer research |
Volume | 66 |
Issue number | 6 |
DOIs | |
State | Published - Mar 15 2006 |
ASJC Scopus subject areas
- Oncology
- Cancer Research