Bcl-2 inhibition of autophagy: A new route to cancer?

Sophie Pattingre, Beth Levine

Research output: Contribution to journalReview article

223 Scopus citations

Abstract

Bcl-2 was the first identified cellular protein that functions as an oncogene by blocking apoptotic cell death. Beclin 1, the first identified mammalian autophagy gene product, is a haplo-insufficient tumor suppressor that was originally isolated as a Bcl-2-interacting protein. We recently showed that Bcl-2 negatively regulates Beclin 1-dependent autophagy and Beclin 1-dependent autophagic cell death. These findings raise the possibility that Bcl-2 family members may function as oncogenes not only by blocking apoptosis but also by blocking autophagy.

Original languageEnglish (US)
Pages (from-to)2885-2888
Number of pages4
JournalCancer research
Volume66
Issue number6
DOIs
StatePublished - Mar 15 2006

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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