BCL1, a murine model of prolymphocytic leukemia. II. Morphology and ultrastructure

M. J. Muirhead; J. M. Holbert; J. W. Uhr; E. S. Vitetta

BCL₁, a murine model of prolymphocytic leukemia. II. Morphology and ultrastructure

M. J. Muirhead, J. M. Holbert, J. W. Uhr, E. S. Vitetta

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Abstract

The transplantable murine B-cell leukemia, BCL₁, was examined by light and electron microscopy. The results show that the BCL₁ cell closely resembles the prolymphocyte of human prolymphocytic leukemia (PLL). The spleen of animals transplanted with BCL₁ is diffusely infiltrated by BCL₁-prolymphocytes. Splenectomized animals given transplants of BCL₁ develop a lymphomalike disease with less leukemia and bone marrow involvement than the nonsplenectomized transplant recipients. Ultrastructural features of the BCL₁ cell are identical in the splenectomized and nonsplenectomized animals.

Original language	English (US)
Pages (from-to)	306-315
Number of pages	10
Journal	American Journal of Pathology
Volume	105
Issue number	3
State	Published - 1981

ASJC Scopus subject areas

Pathology and Forensic Medicine

Cite this

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title = "BCL1, a murine model of prolymphocytic leukemia. II. Morphology and ultrastructure",

abstract = "The transplantable murine B-cell leukemia, BCL1, was examined by light and electron microscopy. The results show that the BCL1 cell closely resembles the prolymphocyte of human prolymphocytic leukemia (PLL). The spleen of animals transplanted with BCL1 is diffusely infiltrated by BCL1-prolymphocytes. Splenectomized animals given transplants of BCL1 develop a lymphomalike disease with less leukemia and bone marrow involvement than the nonsplenectomized transplant recipients. Ultrastructural features of the BCL1 cell are identical in the splenectomized and nonsplenectomized animals.",

author = "Muirhead, {M. J.} and Holbert, {J. M.} and Uhr, {J. W.} and Vitetta, {E. S.}",

year = "1981",

language = "English (US)",

volume = "105",

pages = "306--315",

journal = "American Journal of Pathology",

issn = "0002-9440",

publisher = "Elsevier Inc.",

number = "3",

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T1 - BCL1, a murine model of prolymphocytic leukemia. II. Morphology and ultrastructure

AU - Muirhead, M. J.

AU - Holbert, J. M.

AU - Uhr, J. W.

AU - Vitetta, E. S.

PY - 1981

Y1 - 1981

N2 - The transplantable murine B-cell leukemia, BCL1, was examined by light and electron microscopy. The results show that the BCL1 cell closely resembles the prolymphocyte of human prolymphocytic leukemia (PLL). The spleen of animals transplanted with BCL1 is diffusely infiltrated by BCL1-prolymphocytes. Splenectomized animals given transplants of BCL1 develop a lymphomalike disease with less leukemia and bone marrow involvement than the nonsplenectomized transplant recipients. Ultrastructural features of the BCL1 cell are identical in the splenectomized and nonsplenectomized animals.

AB - The transplantable murine B-cell leukemia, BCL1, was examined by light and electron microscopy. The results show that the BCL1 cell closely resembles the prolymphocyte of human prolymphocytic leukemia (PLL). The spleen of animals transplanted with BCL1 is diffusely infiltrated by BCL1-prolymphocytes. Splenectomized animals given transplants of BCL1 develop a lymphomalike disease with less leukemia and bone marrow involvement than the nonsplenectomized transplant recipients. Ultrastructural features of the BCL1 cell are identical in the splenectomized and nonsplenectomized animals.

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M3 - Article

C2 - 6976124

AN - SCOPUS:0019730609

SN - 0002-9440

VL - 105

SP - 306

EP - 315

JO - American Journal of Pathology

JF - American Journal of Pathology

IS - 3

ER -

BCL₁, a murine model of prolymphocytic leukemia. II. Morphology and ultrastructure

Abstract

ASJC Scopus subject areas

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