BCL1, a murine model of prolymphocytic leukemia. II. Morphology and ultrastructure

M. J. Muirhead, J. M. Holbert, J. W. Uhr, E. S. Vitetta

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The transplantable murine B-cell leukemia, BCL1, was examined by light and electron microscopy. The results show that the BCL1 cell closely resembles the prolymphocyte of human prolymphocytic leukemia (PLL). The spleen of animals transplanted with BCL1 is diffusely infiltrated by BCL1-prolymphocytes. Splenectomized animals given transplants of BCL1 develop a lymphomalike disease with less leukemia and bone marrow involvement than the nonsplenectomized transplant recipients. Ultrastructural features of the BCL1 cell are identical in the splenectomized and nonsplenectomized animals.

Original languageEnglish (US)
Pages (from-to)306-315
Number of pages10
JournalAmerican Journal of Pathology
Volume105
Issue number3
StatePublished - 1981

Fingerprint

Prolymphocytic Leukemia
B-Cell Leukemia
Electron Microscopy
Leukemia
Spleen
Bone Marrow
Transplants
Light

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

BCL1, a murine model of prolymphocytic leukemia. II. Morphology and ultrastructure. / Muirhead, M. J.; Holbert, J. M.; Uhr, J. W.; Vitetta, E. S.

In: American Journal of Pathology, Vol. 105, No. 3, 1981, p. 306-315.

Research output: Contribution to journalArticle

Muirhead, M. J. ; Holbert, J. M. ; Uhr, J. W. ; Vitetta, E. S. / BCL1, a murine model of prolymphocytic leukemia. II. Morphology and ultrastructure. In: American Journal of Pathology. 1981 ; Vol. 105, No. 3. pp. 306-315.
@article{8e5736c41c5b4ef0aaa2146c3c1a81e0,
title = "BCL1, a murine model of prolymphocytic leukemia. II. Morphology and ultrastructure",
abstract = "The transplantable murine B-cell leukemia, BCL1, was examined by light and electron microscopy. The results show that the BCL1 cell closely resembles the prolymphocyte of human prolymphocytic leukemia (PLL). The spleen of animals transplanted with BCL1 is diffusely infiltrated by BCL1-prolymphocytes. Splenectomized animals given transplants of BCL1 develop a lymphomalike disease with less leukemia and bone marrow involvement than the nonsplenectomized transplant recipients. Ultrastructural features of the BCL1 cell are identical in the splenectomized and nonsplenectomized animals.",
author = "Muirhead, {M. J.} and Holbert, {J. M.} and Uhr, {J. W.} and Vitetta, {E. S.}",
year = "1981",
language = "English (US)",
volume = "105",
pages = "306--315",
journal = "American Journal of Pathology",
issn = "0002-9440",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - BCL1, a murine model of prolymphocytic leukemia. II. Morphology and ultrastructure

AU - Muirhead, M. J.

AU - Holbert, J. M.

AU - Uhr, J. W.

AU - Vitetta, E. S.

PY - 1981

Y1 - 1981

N2 - The transplantable murine B-cell leukemia, BCL1, was examined by light and electron microscopy. The results show that the BCL1 cell closely resembles the prolymphocyte of human prolymphocytic leukemia (PLL). The spleen of animals transplanted with BCL1 is diffusely infiltrated by BCL1-prolymphocytes. Splenectomized animals given transplants of BCL1 develop a lymphomalike disease with less leukemia and bone marrow involvement than the nonsplenectomized transplant recipients. Ultrastructural features of the BCL1 cell are identical in the splenectomized and nonsplenectomized animals.

AB - The transplantable murine B-cell leukemia, BCL1, was examined by light and electron microscopy. The results show that the BCL1 cell closely resembles the prolymphocyte of human prolymphocytic leukemia (PLL). The spleen of animals transplanted with BCL1 is diffusely infiltrated by BCL1-prolymphocytes. Splenectomized animals given transplants of BCL1 develop a lymphomalike disease with less leukemia and bone marrow involvement than the nonsplenectomized transplant recipients. Ultrastructural features of the BCL1 cell are identical in the splenectomized and nonsplenectomized animals.

UR - http://www.scopus.com/inward/record.url?scp=0019730609&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019730609&partnerID=8YFLogxK

M3 - Article

VL - 105

SP - 306

EP - 315

JO - American Journal of Pathology

JF - American Journal of Pathology

SN - 0002-9440

IS - 3

ER -