Abstract
Background Blockade of the renin-angiotensin- aldosterone system is a therapeutic mainstay in patients with chronic kidney disease (CKD). However, the renoprotective effect of the novel direct renin inhibitor aliskiren is unknown. Materials and methods We performed a prospective study in 10 CKD patients. All 10 patients with persistent proteinuria (urinary protein-to-creatinin ratio 0.3-3.5 g/g), despite good blood pressure control (<130/80 mmHg) with olmesartan, were started on 150 mg/day aliskiren. Clinical parameters were examined before and after 4, 8, 12, and 16 weeks of treatment. Results Urinary protein-to-creatinine ratio significantly decreased by about 40% at 16 weeks from baseline (P = 0.0002), although estimated glomerular filtration rate and blood pressure did not change throughout the study period. Plasma renin activity also decreased significantly from baseline (P = 0.019), although plasma aldosterone concentration did not change. Conclusions Aliskiren combined with olmesartan reduces proteinuria in CKD patients.
Original language | English (US) |
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Pages (from-to) | 841-845 |
Number of pages | 5 |
Journal | International Urology and Nephrology |
Volume | 44 |
Issue number | 3 |
DOIs | |
State | Published - Jun 2012 |
Keywords
- Aliskiren
- Chronic kidney disease
- Olmesartan
- Proteinuria
ASJC Scopus subject areas
- Nephrology
- Urology