Benefits of enhancing nicotinamide adenine dinucleotide levels in damaged or diseased nerve cells

Andrew A. Pieper, Steven L McKnight

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Three unbiased lines of research have commonly pointed to the benefits of enhanced levels of nicotinamide adenine dinucleotide (NAD+) to diseased or damaged neurons. Mice carrying a triplication of the gene encoding the culminating enzyme in NAD+ salvage from nicotinamide, NMNAT, are protected from a variety of insults to axons. Protection from Wallerian degeneration of axons is also observed in flies and mice bearing inactivating mutations in the SARM1 gene. Functional studies of the SARM1 gene product have revealed the presence of an enzymatic activity directed toward the hydrolysis of NAD+. Finally, an unbiased drug screen performed in living mice led to the discovery of a neuroprotective chemical designated P7C3. Biochemical studies of the P7C3 chemical show that it can enhance recovery of NAD+ from nicotinamide by activating NAMPT, the first enzyme in the salvage pathway. In combination, these three unrelated research endeavors offer evidence of the benefits of enhanced NAD+ levels to damaged neurons.

Original languageEnglish (US)
Pages (from-to)207-217
Number of pages11
JournalCold Spring Harbor Symposia on Quantitative Biology
Volume83
DOIs
StatePublished - Jan 1 2018

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

Fingerprint Dive into the research topics of 'Benefits of enhancing nicotinamide adenine dinucleotide levels in damaged or diseased nerve cells'. Together they form a unique fingerprint.

Cite this