Benign non-X histiocytosis: A unique case bridging several of the non-X histiocytic syndromes

B. M. Coldiron, Ponciano D Cruz, R. G. Freeman, R. D. Sontheimer

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

We present a patient with a papular eruption of 4 years' duration that clinically resembled xanthoma disseminatum or the indeterminate cell disorder. On light microscopy his disorder resembled generalized eruptive histiocytoma or the indeterminate cell disorder. Special stains, cultures, and electron microscopy were noncontributory. Indirect immunofluorescence studies with monoclonal antibodies to cell surface markers demonstrated infiltrating cells of monocyte/macrophage lineage (OKM1, MAC-1, HLA-DR, and HLA-DQ positive) rather than Langerhans or indeterminate cell lineage (OKT6 negative). This case may overlap two or more of the previously reported non-X histiocyte syndromes, suggesting that perhaps these syndromes should be viewed as a spectrum of disease rather than as discrete entities. We recommend performing cell phenotyping on all new cases of non-X histiocytosis because clinical, microscopic, and ultramicroscopic findings often prove inadequate for classification.

Original languageEnglish (US)
Pages (from-to)1282-1289
Number of pages8
JournalJournal of the American Academy of Dermatology
Volume18
Issue number6
StatePublished - 1988

Fingerprint

Histiocytosis
Non-Langerhans-Cell Histiocytosis
Histiocytoma
HLA-DQ Antigens
Histiocytes
HLA-DR Antigens
Cell Lineage
Indirect Fluorescent Antibody Technique
Monocytes
Microscopy
Electron Microscopy
Coloring Agents
Macrophages
Monoclonal Antibodies
Light

ASJC Scopus subject areas

  • Dermatology

Cite this

Benign non-X histiocytosis : A unique case bridging several of the non-X histiocytic syndromes. / Coldiron, B. M.; Cruz, Ponciano D; Freeman, R. G.; Sontheimer, R. D.

In: Journal of the American Academy of Dermatology, Vol. 18, No. 6, 1988, p. 1282-1289.

Research output: Contribution to journalArticle

@article{584230d0c8a64005b970432596d52b9b,
title = "Benign non-X histiocytosis: A unique case bridging several of the non-X histiocytic syndromes",
abstract = "We present a patient with a papular eruption of 4 years' duration that clinically resembled xanthoma disseminatum or the indeterminate cell disorder. On light microscopy his disorder resembled generalized eruptive histiocytoma or the indeterminate cell disorder. Special stains, cultures, and electron microscopy were noncontributory. Indirect immunofluorescence studies with monoclonal antibodies to cell surface markers demonstrated infiltrating cells of monocyte/macrophage lineage (OKM1, MAC-1, HLA-DR, and HLA-DQ positive) rather than Langerhans or indeterminate cell lineage (OKT6 negative). This case may overlap two or more of the previously reported non-X histiocyte syndromes, suggesting that perhaps these syndromes should be viewed as a spectrum of disease rather than as discrete entities. We recommend performing cell phenotyping on all new cases of non-X histiocytosis because clinical, microscopic, and ultramicroscopic findings often prove inadequate for classification.",
author = "Coldiron, {B. M.} and Cruz, {Ponciano D} and Freeman, {R. G.} and Sontheimer, {R. D.}",
year = "1988",
language = "English (US)",
volume = "18",
pages = "1282--1289",
journal = "Journal of the American Academy of Dermatology",
issn = "0190-9622",
publisher = "Mosby Inc.",
number = "6",

}

TY - JOUR

T1 - Benign non-X histiocytosis

T2 - A unique case bridging several of the non-X histiocytic syndromes

AU - Coldiron, B. M.

AU - Cruz, Ponciano D

AU - Freeman, R. G.

AU - Sontheimer, R. D.

PY - 1988

Y1 - 1988

N2 - We present a patient with a papular eruption of 4 years' duration that clinically resembled xanthoma disseminatum or the indeterminate cell disorder. On light microscopy his disorder resembled generalized eruptive histiocytoma or the indeterminate cell disorder. Special stains, cultures, and electron microscopy were noncontributory. Indirect immunofluorescence studies with monoclonal antibodies to cell surface markers demonstrated infiltrating cells of monocyte/macrophage lineage (OKM1, MAC-1, HLA-DR, and HLA-DQ positive) rather than Langerhans or indeterminate cell lineage (OKT6 negative). This case may overlap two or more of the previously reported non-X histiocyte syndromes, suggesting that perhaps these syndromes should be viewed as a spectrum of disease rather than as discrete entities. We recommend performing cell phenotyping on all new cases of non-X histiocytosis because clinical, microscopic, and ultramicroscopic findings often prove inadequate for classification.

AB - We present a patient with a papular eruption of 4 years' duration that clinically resembled xanthoma disseminatum or the indeterminate cell disorder. On light microscopy his disorder resembled generalized eruptive histiocytoma or the indeterminate cell disorder. Special stains, cultures, and electron microscopy were noncontributory. Indirect immunofluorescence studies with monoclonal antibodies to cell surface markers demonstrated infiltrating cells of monocyte/macrophage lineage (OKM1, MAC-1, HLA-DR, and HLA-DQ positive) rather than Langerhans or indeterminate cell lineage (OKT6 negative). This case may overlap two or more of the previously reported non-X histiocyte syndromes, suggesting that perhaps these syndromes should be viewed as a spectrum of disease rather than as discrete entities. We recommend performing cell phenotyping on all new cases of non-X histiocytosis because clinical, microscopic, and ultramicroscopic findings often prove inadequate for classification.

UR - http://www.scopus.com/inward/record.url?scp=0023893732&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023893732&partnerID=8YFLogxK

M3 - Article

C2 - 3385043

AN - SCOPUS:0023893732

VL - 18

SP - 1282

EP - 1289

JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

SN - 0190-9622

IS - 6

ER -