Benign Transient Hyperphosphatasemia Associated With Epstein-Barr Virus Enteritis in a Pediatric Liver Transplant Patient: A Case Report

T. Hranjec, H. Bonatti, A. L. Roman, C. Sifri, S. M. Borowitz, B. H. Barnes, T. R. Flohr, T. L. Pruett, R. G. Sawyer, T. M. Schmitt

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Transient hyperphosphatasemia was found in a 3-year-old male liver transplant recipient. The condition was associated with diarrheal disease due to the Epstein-Barr virus (EBV). Immunosuppression was tapered and valganciclovir prescribed for 3 months, after which the diarrhea resolved and the EBV polymerase chain reaction assays became negative. After 6 months, alkaline phosphatase levels normalized. Isolated elevation of alkaline phosphatase in conjunction with enteric infection is a rare condition. No further diagnostic or therapeutic interventions except treatment of the underlying infection are needed, as this has been shown to be a benign, transient condition.

Original languageEnglish (US)
Pages (from-to)1780-1782
Number of pages3
JournalTransplantation Proceedings
Volume40
Issue number5
DOIs
StatePublished - Jun 1 2008

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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    Hranjec, T., Bonatti, H., Roman, A. L., Sifri, C., Borowitz, S. M., Barnes, B. H., Flohr, T. R., Pruett, T. L., Sawyer, R. G., & Schmitt, T. M. (2008). Benign Transient Hyperphosphatasemia Associated With Epstein-Barr Virus Enteritis in a Pediatric Liver Transplant Patient: A Case Report. Transplantation Proceedings, 40(5), 1780-1782. https://doi.org/10.1016/j.transproceed.2008.04.011