Benign Transient Hyperphosphatasemia Associated With Epstein-Barr Virus Enteritis in a Pediatric Liver Transplant Patient: A Case Report

T. Hranjec; H. Bonatti; A. L. Roman; C. Sifri; S. M. Borowitz; B. H. Barnes; T. R. Flohr; T. L. Pruett; R. G. Sawyer; T. M. Schmitt

doi:10.1016/j.transproceed.2008.04.011

Benign Transient Hyperphosphatasemia Associated With Epstein-Barr Virus Enteritis in a Pediatric Liver Transplant Patient: A Case Report

T. Hranjec, H. Bonatti, A. L. Roman, C. Sifri, S. M. Borowitz, B. H. Barnes, T. R. Flohr, T. L. Pruett, R. G. Sawyer, T. M. Schmitt

Surgery

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6 Scopus citations

Abstract

Transient hyperphosphatasemia was found in a 3-year-old male liver transplant recipient. The condition was associated with diarrheal disease due to the Epstein-Barr virus (EBV). Immunosuppression was tapered and valganciclovir prescribed for 3 months, after which the diarrhea resolved and the EBV polymerase chain reaction assays became negative. After 6 months, alkaline phosphatase levels normalized. Isolated elevation of alkaline phosphatase in conjunction with enteric infection is a rare condition. No further diagnostic or therapeutic interventions except treatment of the underlying infection are needed, as this has been shown to be a benign, transient condition.

Original language	English (US)
Pages (from-to)	1780-1782
Number of pages	3
Journal	Transplantation proceedings
Volume	40
Issue number	5
DOIs	https://doi.org/10.1016/j.transproceed.2008.04.011
State	Published - Jun 2008

ASJC Scopus subject areas

Surgery
Transplantation

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Hranjec, T., Bonatti, H., Roman, A. L., Sifri, C., Borowitz, S. M., Barnes, B. H., Flohr, T. R., Pruett, T. L., Sawyer, R. G., & Schmitt, T. M. (2008). Benign Transient Hyperphosphatasemia Associated With Epstein-Barr Virus Enteritis in a Pediatric Liver Transplant Patient: A Case Report. Transplantation proceedings, 40(5), 1780-1782. https://doi.org/10.1016/j.transproceed.2008.04.011

Hranjec, T, Bonatti, H, Roman, AL, Sifri, C, Borowitz, SM, Barnes, BH, Flohr, TR, Pruett, TL, Sawyer, RG & Schmitt, TM 2008, 'Benign Transient Hyperphosphatasemia Associated With Epstein-Barr Virus Enteritis in a Pediatric Liver Transplant Patient: A Case Report', Transplantation proceedings, vol. 40, no. 5, pp. 1780-1782. https://doi.org/10.1016/j.transproceed.2008.04.011

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title = "Benign Transient Hyperphosphatasemia Associated With Epstein-Barr Virus Enteritis in a Pediatric Liver Transplant Patient: A Case Report",

abstract = "Transient hyperphosphatasemia was found in a 3-year-old male liver transplant recipient. The condition was associated with diarrheal disease due to the Epstein-Barr virus (EBV). Immunosuppression was tapered and valganciclovir prescribed for 3 months, after which the diarrhea resolved and the EBV polymerase chain reaction assays became negative. After 6 months, alkaline phosphatase levels normalized. Isolated elevation of alkaline phosphatase in conjunction with enteric infection is a rare condition. No further diagnostic or therapeutic interventions except treatment of the underlying infection are needed, as this has been shown to be a benign, transient condition.",

author = "T. Hranjec and H. Bonatti and Roman, {A. L.} and C. Sifri and Borowitz, {S. M.} and Barnes, {B. H.} and Flohr, {T. R.} and Pruett, {T. L.} and Sawyer, {R. G.} and Schmitt, {T. M.}",

year = "2008",

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doi = "10.1016/j.transproceed.2008.04.011",

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T2 - A Case Report

AU - Hranjec, T.

AU - Bonatti, H.

AU - Roman, A. L.

AU - Sifri, C.

AU - Borowitz, S. M.

AU - Barnes, B. H.

AU - Flohr, T. R.

AU - Pruett, T. L.

AU - Sawyer, R. G.

AU - Schmitt, T. M.

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AB - Transient hyperphosphatasemia was found in a 3-year-old male liver transplant recipient. The condition was associated with diarrheal disease due to the Epstein-Barr virus (EBV). Immunosuppression was tapered and valganciclovir prescribed for 3 months, after which the diarrhea resolved and the EBV polymerase chain reaction assays became negative. After 6 months, alkaline phosphatase levels normalized. Isolated elevation of alkaline phosphatase in conjunction with enteric infection is a rare condition. No further diagnostic or therapeutic interventions except treatment of the underlying infection are needed, as this has been shown to be a benign, transient condition.

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Benign Transient Hyperphosphatasemia Associated With Epstein-Barr Virus Enteritis in a Pediatric Liver Transplant Patient: A Case Report

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