Beyond the limits: Palladium-N-heterocyclic carbene-based catalytic system enables highly efficient [4+2] benzannulation reactions

Olga V. Zatolochnaya, Alexey V. Galenko, Vladimir Gevorgyan

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

A highly efficient catalytic system for the palladium-catalyzed [4+2] benzannulation reaction of enynes and enynophiles has been developed. The use of an N-heterocyclic carbene-based palladium precursor allowed us to achieve turnover numbers up to 1800. The new catalytic system has enabled an expansion of the scope of the [4+2] homo-benzannulation reaction.

Original languageEnglish (US)
Pages (from-to)1149-1155
Number of pages7
JournalAdvanced Synthesis and Catalysis
Volume354
Issue number6
DOIs
StatePublished - Apr 16 2012
Externally publishedYes

Keywords

  • N-heterocyclic carbenes
  • benzannulation
  • cycloaddition
  • palladium catalysis
  • turnover number

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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