Bidirectional regulation of dendritic voltage-gated potassium channels by the fragile X mental retardation protein

Hye Young Lee, Woo Ping Ge, Wendy Huang, Ye He, Gordon X. Wang, Ashley Rowson-Baldwin, Stephen J. Smith, Yuh Nung Jan, Lily Yeh Jan

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

How transmitter receptors modulate neuronal signaling by regulating voltage-gated ion channel expression remains an open question. Here we report dendritic localization of mRNA of Kv4.2 voltage-gated potassium channel, which regulates synaptic plasticity, and its local translational regulation by fragile X mental retardation protein (FMRP) linked to fragile X syndrome (FXS), the most common heritable mental retardation. FMRP suppression of Kv4.2 is revealed by elevation of Kv4.2 in neurons from fmr1 knockout (KO) mice and in neurons expressing Kv4.2-3'UTR that binds FMRP. Moreover, treating hippocampal slices from fmr1 KO mice with Kv4 channel blocker restores long-term potentiation induced by moderate stimuli. Surprisingly, recovery of Kv4.2 after N-methyl-D-aspartate receptor (NMDAR)-induced degradation also requires FMRP, likely due to NMDAR-induced FMRP dephosphorylation, which turns off FMRP suppression of Kv4.2. Our study of FMRP regulation of Kv4.2 deepens our knowledge of NMDAR signaling and reveals a FMRP target of potential relevance to FXS.

Original languageEnglish (US)
Pages (from-to)630-642
Number of pages13
JournalNeuron
Volume72
Issue number4
DOIs
StatePublished - Nov 17 2011

ASJC Scopus subject areas

  • Neuroscience(all)

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    Lee, H. Y., Ge, W. P., Huang, W., He, Y., Wang, G. X., Rowson-Baldwin, A., Smith, S. J., Jan, Y. N., & Jan, L. Y. (2011). Bidirectional regulation of dendritic voltage-gated potassium channels by the fragile X mental retardation protein. Neuron, 72(4), 630-642. https://doi.org/10.1016/j.neuron.2011.09.033