Bifunctional thiosialosides inhibit influenza virus

Yang Yang, Yun He, Xingzhe Li, Hieu Dinh, Suri S. Iyer

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

We have synthesized a panel of bivalent S-sialoside analogues, with modifications at the 4 position, as inhibitors of influenza virus. These first generation compounds show IC50 values ranging from low micromolar to high nanomolar in enzyme inhibition and plaque reduction assays with two intact viruses, Influenza H1N1 (A/California/07/2009) and H3N2 (A/Hongkong/8/68).

Original languageEnglish (US)
Pages (from-to)636-643
Number of pages8
JournalBioorganic and Medicinal Chemistry Letters
Volume24
Issue number2
DOIs
StatePublished - Jan 15 2014
Externally publishedYes

Keywords

  • Bifunctional
  • Glycoconjugates
  • Influenza virus
  • Inhibitors
  • Sialic acid

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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