Bifunctional thiosialosides inhibit influenza virus

Yang Yang; Yun He; Xingzhe Li; Hieu Dinh; Suri S. Iyer

doi:10.1016/j.bmcl.2013.11.077

Bifunctional thiosialosides inhibit influenza virus

Yang Yang, Yun He, Xingzhe Li, Hieu Dinh, Suri S. Iyer

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

We have synthesized a panel of bivalent S-sialoside analogues, with modifications at the 4 position, as inhibitors of influenza virus. These first generation compounds show IC₅₀ values ranging from low micromolar to high nanomolar in enzyme inhibition and plaque reduction assays with two intact viruses, Influenza H1N1 (A/California/07/2009) and H3N2 (A/Hongkong/8/68).

Original language	English (US)
Pages (from-to)	636-643
Number of pages	8
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	24
Issue number	2
DOIs	https://doi.org/10.1016/j.bmcl.2013.11.077
State	Published - Jan 15 2014
Externally published	Yes

Keywords

Bifunctional
Glycoconjugates
Influenza virus
Inhibitors
Sialic acid

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2013.11.077

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title = "Bifunctional thiosialosides inhibit influenza virus",

abstract = "We have synthesized a panel of bivalent S-sialoside analogues, with modifications at the 4 position, as inhibitors of influenza virus. These first generation compounds show IC50 values ranging from low micromolar to high nanomolar in enzyme inhibition and plaque reduction assays with two intact viruses, Influenza H1N1 (A/California/07/2009) and H3N2 (A/Hongkong/8/68).",

keywords = "Bifunctional, Glycoconjugates, Influenza virus, Inhibitors, Sialic acid",

author = "Yang Yang and Yun He and Xingzhe Li and Hieu Dinh and Iyer, {Suri S.}",

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AU - Yang, Yang

AU - He, Yun

AU - Li, Xingzhe

AU - Dinh, Hieu

AU - Iyer, Suri S.

PY - 2014/1/15

Y1 - 2014/1/15

N2 - We have synthesized a panel of bivalent S-sialoside analogues, with modifications at the 4 position, as inhibitors of influenza virus. These first generation compounds show IC50 values ranging from low micromolar to high nanomolar in enzyme inhibition and plaque reduction assays with two intact viruses, Influenza H1N1 (A/California/07/2009) and H3N2 (A/Hongkong/8/68).

AB - We have synthesized a panel of bivalent S-sialoside analogues, with modifications at the 4 position, as inhibitors of influenza virus. These first generation compounds show IC50 values ranging from low micromolar to high nanomolar in enzyme inhibition and plaque reduction assays with two intact viruses, Influenza H1N1 (A/California/07/2009) and H3N2 (A/Hongkong/8/68).

KW - Bifunctional

KW - Glycoconjugates

KW - Influenza virus

KW - Inhibitors

KW - Sialic acid

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 2

ER -

Bifunctional thiosialosides inhibit influenza virus

Abstract

Keywords

ASJC Scopus subject areas

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