TY - JOUR
T1 - Bilateral central lipid infiltrates of the cornea
AU - Friedlaender, Mitchell H.
AU - Cavanagh, Harrison D
AU - Sullivan, William R.
AU - Gallagher, Michael J.
AU - Dickersin, G. Richard
N1 - Funding Information:
A 55-year-old woman had documented clear corneas and 6/6 (20/20) vision in both eyes until three years before admission. She then developed sudden onset of severe ocular pain, tearing, and photophobia accompanied by a diffuse erythematous skin From the Department of Cornea Research (Dr. Friedlaender), Eye Research, Eye Research Institute of Retina Foundation; Cornea Service (Dr. Cavanagh), Massachusetts Eye and Ear Infirmary; Department of Pathology (Drs. Gallagher and Dicker-sin), Massachusetts General Hospital; and the Departments of Ophthalmology (Drs. Friedlaender and Cavanagh) and Pathology (Drs. Gallagher and Dickersin), Harvard Medical School, Boston, Massachusetts. This work was supported in part by Research Grants EY-00208, and EY-01647, and Institutional National Research Service Award No. EY-07018.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1977/12
Y1 - 1977/12
N2 - A 55-year-old woman developed a skin rash and lipid deposition centrally in previously normal corneas. Despite a family history of coronary artery disease, no serum lipid abnormality was detected. Lipid droplets and granules were deposited throughout the corneal epithelium and stroma. Histochemical stains were positive only for phosopholipid and galactolipid. After a keratoplasty, deposition of similar lipid material recurred in the graft. An inflammatory process and increased corneoscelerallimbal vascular permeability may have accounted for the unusual corneal findings in this patient.
AB - A 55-year-old woman developed a skin rash and lipid deposition centrally in previously normal corneas. Despite a family history of coronary artery disease, no serum lipid abnormality was detected. Lipid droplets and granules were deposited throughout the corneal epithelium and stroma. Histochemical stains were positive only for phosopholipid and galactolipid. After a keratoplasty, deposition of similar lipid material recurred in the graft. An inflammatory process and increased corneoscelerallimbal vascular permeability may have accounted for the unusual corneal findings in this patient.
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U2 - 10.1016/0002-9394(77)90496-2
DO - 10.1016/0002-9394(77)90496-2
M3 - Article
C2 - 339720
AN - SCOPUS:0017605702
SN - 0002-9394
VL - 84
SP - 781
EP - 787
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 6
ER -