Bilateral lung transplantation for cystic fibrosis

J. C. Ramirez, G. A. Patterson, T. L. Winton, A. L. De Hoyos, J. D. Miller, J. R. Maurer

Research output: Contribution to journalArticle

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Abstract

Between March 1988 and March 1991, 17 patients underwent bilateral lung transplantation for end-stage lung disease caused by cystic fibrosis. There were 11 male and six female patients. Ages ranged from 19 to 41 years (mean age 28 years). Preoperative mean arterial oxygen tension with the patient breathing room air was 54 ± 6 mm Hg; forced vital capacity, 1.8 ± 0.7 L; forced expiratory volume in 1 second, 0.9 ± 0.3 L; and 6-minute walk test, 506 ± 44 m. Immunosuppression consisted of cyclosporine, azathioprine, and prednisone. Induction immunosuppression was obtained with Minnesota antilymphocyte globulin. All patients received perioperative antibiotics according to sputum cultures and sensitivities. There were six operative deaths, four of which resulted from bacterial infection. Two patients required a second transplantation, one receiving a single lung and one undergoing bilateral lung replacement. Significant functional improvement was observed in all survivors. At 3 months follow-up, mean arterial oxygen tension on room air was 95 ± 6 mm Hg (p < 0.01); forced vital capacity, 3 ± 0.8 L (p < 0.01); forced expiratory volume in 1 second, 2.6 ± 0.9 L (p < 0.01); and 6-minute walk test, 678 ± 47 m (p < 0.01). The actuarial survival rate was 66% at 3 months and 58% at 6, 12, and 24 months. The most frequent cause of morbidity and mortality was acute pneumonia resulting from Pseudomonas cepacia. For patients with respiratory failure caused by cystic fibrosis, bilateral lung transplantation is an effective treatment option associated with significant functional improvement.

Original languageEnglish (US)
Pages (from-to)287-294
Number of pages8
JournalJournal of Thoracic and Cardiovascular Surgery
Volume103
Issue number2
StatePublished - Jan 1 1992

Fingerprint

Lung Transplantation
Cystic Fibrosis
Vital Capacity
Forced Expiratory Volume
Immunosuppression
Arterial Pressure
Air
Oxygen
Burkholderia cepacia
Patients' Rooms
Lung
Antilymphocyte Serum
Azathioprine
Prednisone
Sputum
Bacterial Infections
Respiratory Insufficiency
Cyclosporine
Lung Diseases
Survivors

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Ramirez, J. C., Patterson, G. A., Winton, T. L., De Hoyos, A. L., Miller, J. D., & Maurer, J. R. (1992). Bilateral lung transplantation for cystic fibrosis. Journal of Thoracic and Cardiovascular Surgery, 103(2), 287-294.

Bilateral lung transplantation for cystic fibrosis. / Ramirez, J. C.; Patterson, G. A.; Winton, T. L.; De Hoyos, A. L.; Miller, J. D.; Maurer, J. R.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 103, No. 2, 01.01.1992, p. 287-294.

Research output: Contribution to journalArticle

Ramirez, JC, Patterson, GA, Winton, TL, De Hoyos, AL, Miller, JD & Maurer, JR 1992, 'Bilateral lung transplantation for cystic fibrosis', Journal of Thoracic and Cardiovascular Surgery, vol. 103, no. 2, pp. 287-294.
Ramirez JC, Patterson GA, Winton TL, De Hoyos AL, Miller JD, Maurer JR. Bilateral lung transplantation for cystic fibrosis. Journal of Thoracic and Cardiovascular Surgery. 1992 Jan 1;103(2):287-294.
Ramirez, J. C. ; Patterson, G. A. ; Winton, T. L. ; De Hoyos, A. L. ; Miller, J. D. ; Maurer, J. R. / Bilateral lung transplantation for cystic fibrosis. In: Journal of Thoracic and Cardiovascular Surgery. 1992 ; Vol. 103, No. 2. pp. 287-294.
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