Bilateral paget disease of the nipple associated with lobular carcinoma in situ: Application of immunohistochemistry to a rare finding

Sunati Sahoo, Ileana Green, Paul P. Rosen

Research output: Contribution to journalArticle

17 Scopus citations


We report synchronous bilateral Paget disease derived from lobular carcinoma in situ in a 53-year-old woman who underwent bilateral mastectomy. The epidermis of both nipples contained small cells with a moderate amount of pale-staining cytoplasm. The nuclei had fine chromatin and identifiable nucleoli. The cells were strongly immunoreactive with cytokeratin 7 and displayed nuclear estrogen receptor reactivity. The underlying mammary gland showed involvement by lobular carcinoma in situ with pagetoid spread into lactiferous ducts, which was confirmed by lack of immunoreactivity for E-cadherin.

Original languageEnglish (US)
Pages (from-to)90-92
Number of pages3
JournalArchives of Pathology and Laboratory Medicine
Issue number1
StatePublished - Feb 2 2002


ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

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