TY - JOUR
T1 - Bile acids and colon cancer
T2 - Solving the puzzle with nuclear receptors
AU - Degirolamo, Chiara
AU - Modica, Salvatore
AU - Palasciano, Giuseppe
AU - Moschetta, Antonio
N1 - Funding Information:
We are grateful to C. Gardmo for critically reading the manuscript and R. Le Donne for artwork. We apologize to our distinguished colleagues whose work was not cited owing to the format limitations. A.M. is funded by the Italian Association for Cancer Research (AIRC, IG 10416), Italian Ministry of University (FIRB IDEAS RBID08C9N7), Italian Ministry of Health (Young Researchers Grant GR-2008-1143546), European Community's Seventh Framework Program FP7/2007–2013 under Grant Agreement No. 202272 (LipidomicNet), Telethon (GPP08259), Cariplo (Milan), Natural Pharma International (NPI Biotech) and University of Bari, Italy (IDEA 2008 GRBA0802SJ).
PY - 2011/10
Y1 - 2011/10
N2 - Colorectal cancer is the third most common malignancy worldwide and is often linked to obesity, a sedentary lifestyle, carbohydrate- and fat-rich diets and elevated fecal excretion of secondary bile acids. Accumulation of toxic bile acids triggers oxidative damage, mitochondrial dysfunction and tumor progression. Nuclear receptors are transcription factors crucially involved in the regulation of bile acid metabolism and detoxification, and their activation may confer protection from bile acid tumor-promoting activity. In this review, we explore the tangled relationships among bile acids, nuclear receptors and the intestinal epithelium, with particular emphasis on the role of the farnesoid X receptor in colorectal cancer prevention and on novel nuclear receptor-based approaches to expand the portfolio of chemotherapeutic agents.
AB - Colorectal cancer is the third most common malignancy worldwide and is often linked to obesity, a sedentary lifestyle, carbohydrate- and fat-rich diets and elevated fecal excretion of secondary bile acids. Accumulation of toxic bile acids triggers oxidative damage, mitochondrial dysfunction and tumor progression. Nuclear receptors are transcription factors crucially involved in the regulation of bile acid metabolism and detoxification, and their activation may confer protection from bile acid tumor-promoting activity. In this review, we explore the tangled relationships among bile acids, nuclear receptors and the intestinal epithelium, with particular emphasis on the role of the farnesoid X receptor in colorectal cancer prevention and on novel nuclear receptor-based approaches to expand the portfolio of chemotherapeutic agents.
UR - http://www.scopus.com/inward/record.url?scp=80052771111&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80052771111&partnerID=8YFLogxK
U2 - 10.1016/j.molmed.2011.05.010
DO - 10.1016/j.molmed.2011.05.010
M3 - Review article
C2 - 21724466
AN - SCOPUS:80052771111
SN - 1471-4914
VL - 17
SP - 564
EP - 572
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
IS - 10
ER -