@article{a1eefc9e95e548438579d54bc32e384a,
title = "Biliopancreatic Diversion Induces Greater Metabolic Improvement Than Roux-en-Y Gastric Bypass",
abstract = "Diabetes remission is greater after biliopancreatic diversion (BPD) than Roux-en-Y gastric bypass (RYGB) surgery. Harris and Kayser et al. report that in individuals matched for percentage weight loss after surgery, BPD induces the same improvement in β cell function but a greater improvement in insulin sensitivity than RYGB.",
keywords = "bariatric surgery, insulin sensitivity, obesity",
author = "Harris, {Lydia Ann} and Kayser, {Brandon D.} and Consuelo Cefalo and Luca Marini and Watrous, {Jeramie D.} and Jeffrey Ding and Mohit Jain and McDonald, {Jeffrey G.} and Thompson, {Bonne M.} and Elisa Fabbrini and Eagon, {J. Christopher} and Patterson, {Bruce W.} and Bettina Mittendorfer and Geltrude Mingrone and Samuel Klein",
note = "Funding Information: The authors thank Jennifer Shew, Freida Custodio, and Dr. Adewole L. Okunade for their technical assistance in processing and analyzing study samples; Drs. Jiye Cheng and Jeff Gordon for analysis of plasma short-chain fatty acid concentrations; Prof. Bart Staels for insightful discussions regarding bile acid physiology; and the study subjects for their participation. This study was supported by National Institutes of Health grants DK101578, DK56341 (Nutrition Obesity Research Center), DK20579 (Diabetes Research Center), UL1 TR000448 (Clinical Translational Science Award, including KL2 sub-award TR 000450), T32HL130357, K01DK116917, S10OD020025, R01ES027595, and HL20948 and the Pershing Square Foundation. S.K. G.M. and E.F. designed the study. L.-A.H. B.D.K. and B.W.P. analyzed the data and conducted mathematical modeling. C.C. L.M. and G.M. conducted the clinical studies. J.D.W. J.D. and M.J. conducted the metabolomics analyses. J.G.M. and B.M.T. conducted the bile acid analyses. L.-A.H. B.D.K. B.M. J.C.E. G.M. and S.K. interpreted the data and wrote the manuscript. All authors critically reviewed and edited the manuscript. S.K. is a shareholder of Aspire Bariatrics, receives research funding from Merck Research Laboratories and Janssen Pharmaceuticals, and serves as a member of the Merck Global Diabetes and Metabolism Scientific Advisory Board. The other authors have nothing to disclose. Funding Information: S.K. is a shareholder of Aspire Bariatrics, receives research funding from Merck Research Laboratories and Janssen Pharmaceuticals , and serves as a member of the Merck Global Diabetes and Metabolism Scientific Advisory Board. The other authors have nothing to disclose. Funding Information: The authors thank Jennifer Shew, Freida Custodio, and Dr. Adewole L. Okunade for their technical assistance in processing and analyzing study samples; Drs. Jiye Cheng and Jeff Gordon for analysis of plasma short-chain fatty acid concentrations; Prof. Bart Staels for insightful discussions regarding bile acid physiology; and the study subjects for their participation. This study was supported by National Institutes of Health grants DK101578 , DK56341 (Nutrition Obesity Research Center), DK20579 (Diabetes Research Center), UL1 TR000448 (Clinical Translational Science Award, including KL2 sub-award TR 000450), T32HL130357 , K01DK116917 , S10OD020025 , R01ES027595 , and HL20948 and the Pershing Square Foundation . Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2019",
month = nov,
day = "5",
doi = "10.1016/j.cmet.2019.09.002",
language = "English (US)",
volume = "30",
pages = "855--864.e3",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "5",
}