Binding and stability determinants of the PPARγ nuclear receptor-coactivator interface as revealed by shotgun alanine scanning and in vivo selection

Engineering & Materials Science

• Peroxisome Proliferator-Activated Receptors 100%
• Cytoplasmic and Nuclear Receptors 92%
• Scanning 37%
• Epitopes 26%
• Proteins 22%
• Peptides 10%
• Enzymes 9%
• Clamping devices 9%
• Stretching 8%
• Throughput 5%

Medicine & Life Sciences

• Nuclear Receptor Coactivators 79%
• Peroxisome Proliferator-Activated Receptors 59%
• Firearms 55%
• Alanine 49%
• Mediator Complex Subunit 1 14%
• Epitopes 14%
• Protein Stability 9%
• Cytoplasmic and Nuclear Receptors 8%
• Proteins 6%
• Peptides 5%
• Enzymes 4%

Chemical Compounds

• Epitope 49%
• Alanine 47%
• Peptide 14%
• Protein 10%