Binding sites for endothelin-1 in rat tissues: An autoradiographic study

C. Koseki, M. Imai, Y. Hirata, Masashi Yanagisawa, T. Masaki

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

By tissue autoradiography in the rat, we demonstrated that receptors for endothelin-1 (ET-1) were distributed not only in the cardiovascular system but also in the noncardiovascular organs including the brain, lung, intestine, etc. In the brain, the receptors were mainly found in the basal ganglia and brainstem, in which nuclei are known to be cardiovascular regulatory sites. In addition to its direct vasoconstricting action, ET-1 may exert neural cardiovascular control as a neuropeptide.

Original languageEnglish (US)
Pages (from-to)S153-S154
JournalJournal of Cardiovascular Pharmacology
Volume13
DOIs
StatePublished - 1989

Keywords

  • Autoradiography
  • Cardiovascular regulatory nucleus
  • Central nervous system
  • Endothelin-1
  • Receptor
  • Vasoconstrictor

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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