Binding sites for endothelin-1 in rat tissues: An autoradiographic study

C. Koseki, M. Imai, Y. Hirata, Masashi Yanagisawa, T. Masaki

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By tissue autoradiography in the rat, we demonstrated that receptors for endothelin-1 (ET-1) were distributed not only in the cardiovascular system but also in the noncardiovascular organs including the brain, lung, intestine, etc. In the brain, the receptors were mainly found in the basal ganglia and brainstem, in which nuclei are known to be cardiovascular regulatory sites. In addition to its direct vasoconstricting action, ET-1 may exert neural cardiovascular control as a neuropeptide.

Original languageEnglish (US)
JournalJournal of Cardiovascular Pharmacology
Issue numberSUPPL. 5
Publication statusPublished - 1989


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology

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