Bioavailability of citrate from two different preparations of potassium citrate

J. A. Harvey, M. M. Zobitz, C. Y C Pak

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Abstract

The bioavailability of citrate from two different preparations of potassium citrate was examined in eighteen normal volunteers during three phases of study. After stabilization on a constant metabolic diet, subjects took a single dose of placebo, 'slow-release' potassium citrate tablets (60 meq) or rapid-release liquid potassium citrate preparation (60 meq). Timed urine specimens were collected for 24 hours and analyzed for citrate, potassium, and pH. Similar biochemical findings were observed following administration of the two different preparations with the onset and decline of changes being slightly more rapid for the liquid potassium citrate than the tablet preparation. These equivalent bioavailability data indicate that the liquid preparation is a comparable therapeutic alternative to the tablet form.

Original languageEnglish (US)
Pages (from-to)338-341
Number of pages4
JournalJournal of Clinical Pharmacology
Volume29
Issue number4
StatePublished - 1989

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Potassium Citrate
Citric Acid
Biological Availability
Tablets
Healthy Volunteers
Placebos
Urine
Diet

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Bioavailability of citrate from two different preparations of potassium citrate. / Harvey, J. A.; Zobitz, M. M.; Pak, C. Y C.

In: Journal of Clinical Pharmacology, Vol. 29, No. 4, 1989, p. 338-341.

Research output: Contribution to journalArticle

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