Biochemical analysis of cell adhesion to a substratum and its possible relevance to cell metastasis.

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

The evidence is reviewed that two types of cell attachment occur, depending upon the presence or absence of serum in the medium. In the absence of serum, attachment has many characteristics of a nonphysiological process. In the presence of serum, attachment occurs as a series of steps: adsorption of serum components onto the substratum, contact between the cell and substratum, initial attachment, and progressive attachments leading to cell spreading. Although there is a close interdependence of these events, they could be experimentally distinguished. Studies are reported indicating that cell spreading requires the adsorption of a specific serum glycoprotein onto the substratum surface. The relationship between cell adhesiveness and the altered behavior of malignant cells is discussed.

Original languageEnglish (US)
Pages (from-to)227-236
Number of pages10
JournalProgress in clinical and biological research
Volume9
StatePublished - Dec 1 1976

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Biochemical analysis of cell adhesion to a substratum and its possible relevance to cell metastasis.'. Together they form a unique fingerprint.

  • Cite this