Biochemical correlates of illness and recovery in Reye's syndrome

Doris Trauner, Lawrence Sweetman, Janette Holm, Stanko Kulovich, William L. Nyhan

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Eight patients with Reye's syndrome were followed through the course of their disease with serial measurements of serum concentrations of ammonia, short‐chain organic acids, and amino acids. Correlations were made between clinical status and biochemical alterations. Elevated short‐chain fatty acids, hyperammonemia, and hyperaminoacidemia were found in all patients studied. Clinical improvement appeared to correlate most closely with clearance of short‐chain fatty acids from the serum. These observations suggest that the clinical symptoms are at least in part related to organic acidemia and that treatment directed toward the rapid clearance of these compounds from the system is reasonable.

Original languageEnglish (US)
Pages (from-to)238-241
Number of pages4
JournalAnnals of Neurology
Volume2
Issue number3
DOIs
StatePublished - Sep 1977
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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