Biochemical Genetics of Neurologic Disease

Peter T. Rowley, Phillip D. Swanson, Donald F. Farrell, Thomas D. Bird, Arno G. Motulsky, Roger N. Rosenberg

Research output: Contribution to journalLetter

Abstract

To the Editor: The review by Dr. Rosenberg in the November 12 issue1 documents the impressive contribution of biochemical genetics to the understanding of neurologic disease. His discussion of genetic linkage may lead the reader to confuse linkage and association. The statement that “Myasthenia gravis may also be linked to HLA-B8” is not quite correct for several reasons. Certainly it is the genetic susceptibility to myasthenia gravis that was intended here, since the disease has a major environmental component, in view of its low familial frequency, its episodic manifestations, and its autoimmune features. More important, “linkage” refers to loci situated.

Original languageEnglish (US)
Pages (from-to)681
Number of pages1
JournalNew England Journal of Medicine
Volume306
Issue number11
DOIs
StatePublished - Mar 18 1982

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Inborn Genetic Diseases
Myasthenia Gravis
Nervous System Diseases
Molecular Biology
HLA-B8 Antigen
Genetic Linkage
Genetic Predisposition to Disease

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Rowley, P. T., Swanson, P. D., Farrell, D. F., Bird, T. D., Motulsky, A. G., & Rosenberg, R. N. (1982). Biochemical Genetics of Neurologic Disease. New England Journal of Medicine, 306(11), 681. https://doi.org/10.1056/NEJM198203183061115

Biochemical Genetics of Neurologic Disease. / Rowley, Peter T.; Swanson, Phillip D.; Farrell, Donald F.; Bird, Thomas D.; Motulsky, Arno G.; Rosenberg, Roger N.

In: New England Journal of Medicine, Vol. 306, No. 11, 18.03.1982, p. 681.

Research output: Contribution to journalLetter

Rowley, PT, Swanson, PD, Farrell, DF, Bird, TD, Motulsky, AG & Rosenberg, RN 1982, 'Biochemical Genetics of Neurologic Disease', New England Journal of Medicine, vol. 306, no. 11, pp. 681. https://doi.org/10.1056/NEJM198203183061115
Rowley, Peter T. ; Swanson, Phillip D. ; Farrell, Donald F. ; Bird, Thomas D. ; Motulsky, Arno G. ; Rosenberg, Roger N. / Biochemical Genetics of Neurologic Disease. In: New England Journal of Medicine. 1982 ; Vol. 306, No. 11. pp. 681.
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