Biochemistry and physiological importance of heme proteins as oxygen sensors

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Abstract

In heme-based sensors, a ligand-induced conformational change, initiated at a hemebinding domain, controls the function of a separate transducing domain. For such sensors, there is a considerable range in both the types of heme-binding domains that are possible and the activities to which they can couple. For example, in mammalian soluble guanylyl cyclases (sGC), coupling of a sensory heme-binding domain to a guanylyl cyclase domain permits NO regulation of cGMP, levels (3). A three-dimensional structure is not yet available for the heme-binding domain of sGC, but its sequence suggests that it will not resemble any known heme-protein fold. In the CooA protein of Rhodospirullum rubrum, coupling of a different type of hemebinding domain to a DNA-binding domain allows CO-regulated induction of genes for CO catabolism (4,5). The CooA. protein is unique in that it structurally resembles a catabolite-activator protein (CAP) with heme replacing cAMP. in the regulatory domain (6). So far, O2 signal transduction has offered the greatest variety in the processes controlled, the sensory domains used, and the transducer domains coupled (7). The processes regulated by O2 include nitrogen fixation, cellulose production, and aerotaxis (8-13). At least two types of O2-sensing domains have been identified, one that has a heme-PAS fold and another that is likely to have a myoglobin fold (12,14). The transducing domains are even more varied. They include chemotaxis domains, phosphodiesterase, and histidine-protein kinase domains (2,10,11,15).

Original languageEnglish (US)
Title of host publicationOxygen Sensing
Subtitle of host publicationResponses and Adaption to Hypoxia
PublisherCRC Press
Pages6-22
Number of pages17
ISBN (Electronic)9780824748456
ISBN (Print)9780824709600
StatePublished - Jan 1 2003

Fingerprint

Hemeproteins
Heme
Biochemistry
Oxygen
Carbon Monoxide
Cyclic AMP Receptor Protein
Nitrogen Fixation
Myoglobin
Guanylate Cyclase
Phosphoric Diester Hydrolases
Chemotaxis
Transducers
Cellulose
Signal Transduction
Proteins
Ligands
DNA
Genes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gilles-Gonzalez, M-A. (2003). Biochemistry and physiological importance of heme proteins as oxygen sensors. In Oxygen Sensing: Responses and Adaption to Hypoxia (pp. 6-22). CRC Press.

Biochemistry and physiological importance of heme proteins as oxygen sensors. / Gilles-Gonzalez, Marie-Alda.

Oxygen Sensing: Responses and Adaption to Hypoxia. CRC Press, 2003. p. 6-22.

Research output: Chapter in Book/Report/Conference proceedingChapter

Gilles-Gonzalez, M-A 2003, Biochemistry and physiological importance of heme proteins as oxygen sensors. in Oxygen Sensing: Responses and Adaption to Hypoxia. CRC Press, pp. 6-22.
Gilles-Gonzalez M-A. Biochemistry and physiological importance of heme proteins as oxygen sensors. In Oxygen Sensing: Responses and Adaption to Hypoxia. CRC Press. 2003. p. 6-22
Gilles-Gonzalez, Marie-Alda. / Biochemistry and physiological importance of heme proteins as oxygen sensors. Oxygen Sensing: Responses and Adaption to Hypoxia. CRC Press, 2003. pp. 6-22
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